甲强龙冲击治疗小儿神经免疫性疾病的效果及对免疫球蛋白指标的影响分析  

Analysis on Effect of Methylprednisolone Pulse Therapy in Children with Neuroimmune Diseases and Its Influence on Immunoglobulin Indexes

作　　者：张素珍 周永博 Zhang Su-zhen;Zhou Yong-bo(Department Pediatrics,Chengwu County People's Hospital,Heze 274200,Shandong Province,China;Dongda Hospital of Traditional Chinese Medicine of Chengwu County,Heze 274200,Shandong Province,China)

机构地区：[1]成武县人民医院儿科,山东菏泽274200 [2]成武县东大中医院,山东菏泽274200

出　　处：《中国社区医师》2023年第3期48-50,共3页Chinese Community Doctors

摘　　要：目的:探析在小儿神经免疫性疾病中应用甲强龙冲击治疗的效果及对免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)的影响。方法:选取2021年1-12月成武县人民医院收治的82例小儿神经免疫性疾病患儿作为研究对象,根据随机抽签法分为对比组和探析组,各41例。对比组行常规治疗,探析组行甲强龙冲击治疗。对比两组临床疗效,免疫球蛋白指标(IgG、IgM、IgA)及不良反应发生情况。结果:探析组总有效率高于对比组,差异有统计学意义(P=0.023)。治疗前,两组IgA、IgM、IgG水平比较,差异无统计学意义(P>0.05);治疗后,探析组IgA、IgM、IgG水平均低于对比组,差异有统计学意义(P=0.000)。探析组不良反应发生率低于对比组,差异有统计学意义(P=0.034)。结论:甲强龙冲击治疗小儿神经免疫性疾病能有效提升总有效率,降低患儿的IgA、IgM、IgG水平及不良反应发生率,有较高的推广价值。Objective:To explore the effect of methylprednisolone pulse therapy in the children with neuroimmune diseases and its influence on immunoglobulin G(IgG),immunoglobulin M(IgM),immunoglobulin A(IgA) indexes.Methods:A total of 82children with neuroimmune diseases who were treated in Chengwu County People’ s Hospital from January 2021 to December2021 were selected as the study subjects.They were divided into control group and exploration group according to random sortition method,with 41 cases in each group.The control group received conventional treatment,and the exploration group received methylprednisolone pulse therapy.The clinical efficacy,immunoglobulin indexes(IgG,IgM,IgA) and incidence of adverse reactions between two groups were compared.Results:The total effective rate in the exploration group was higher than that in the control group,and the difference was statistically significant(P=0.023).Before treatment,there was no significant difference in the levels of IgA,IgM and IgG between the two groups(P>0.05).After treatment,the levels of IgA,IgM and IgG in the exploration group were lower than those in the control group,and the differences were statistically significant(P=0.000).The incidence of adverse reactions in the exploration group was lower than that in the control group,and the difference was statistically significant(P=0.034).Conclusion:Methylprednisolone pulse therapy in the children with neuroimmune diseases can effectively improve the total effective rate,reduce the levels of IgG,IgM,IgA and the incidence of adverse reactions,which has high promotion value.

关 键 词：神经免疫性疾病 甲强龙 冲击治疗 免疫功能 

分 类 号：R748[医药卫生—神经病学与精神病学]