东莨菪碱与前庭习服训练防治晕动病的效果观察  

Effect observation of scopolamine and vestibular habituation training on motion sickness

作　　者：张尧[1] 马小琦[1] 曹晓攀 徐冰[1] 任莉[1] 隋轶[1] ZHANG Yao;MA Xiao-qi;CAO Xiao-pan(Department of Neurology,Shenyang First People's Hospital,Shenyang 110041,China)

机构地区：[1]沈阳市第一人民医院神经内科,110041

出　　处：《中国现代药物应用》2023年第3期45-48,共4页Chinese Journal of Modern Drug Application

基　　金：吴阶平医学基金会临床科研专项资助基金(项目编号:320.6750.18323)。

摘　　要：目的 研究东莨菪碱与前庭习服训练防治晕动病(MS)的临床效果。方法 54例MS患者,按随机数字表法分为参照组和实验组,各27例。参照组使用东莨菪碱进行治疗,实验组使用前庭习服训练进行治疗。比较两组患者治疗前后总症状评分及不良事件发生情况。结果 治疗前及治疗当天、治疗后1周、治疗后1个月,参照组总症状评分分别为(15.56±5.31)、(9.16±5.89)、(14.72±4.36)、(15.83±4.41)分,实验组分别为(16.41±10.03)、(4.27±3.11)、(4.13±2.63)、(3.76±2.85)分。参照组治疗当天总症状评分低于治疗前,差异有统计学意义(P<0.05);实验组治疗当天、治疗后1周、治疗后1个月总症状评分均低于治疗前及参照组,差异有统计学意义(P<0.05);参照组治疗后1周及1个月总症状评分与治疗前比较,差异无统计学意义(P>0.05)。实验组不良事件发生率11.11%低于参照组的22.22%,但差异无统计学意义(P>0.05)。结论 针对MS,前庭习服训练与东莨菪碱相比具有更明显的防治效果,可使患者症状明显减轻,且不增加患者的不良事件。Objective To study the clinical effect of scopolamine and vestibular habituation training on motion sickness(MS). Methods A total of 54 patients with MS were divided into a reference group and an experimental group according to the random numerical table, with 27 patients in each group. The reference group was treated with scopolamine, and the experimental group was treated with vestibular habituation training.The total symptom score before and after treatment, and the occurrence of adverse reactions were compared between the two groups. Results The total symptom scores were(15.56±5.31),(9.16±5.89),(14.72±4.36),and(15.83±4.41) points in the reference group before and on the day of treatment, 1 week after treatment, and 1 month after treatment, and(16.41±10.03),(4.27±3.11),(4.13±2.63), and(3.76±2.85) points in the reference group. The total symptom score in the reference group on the day of treatment was lower than that before treatment in this group, and the difference was statistically significant(P<0.05). The total symptom scores on the day of treatment, 1 week after treatment and 1 month after treatment in the experimental group were lower than that before treatment in this group and those in the reference group, and the differences were statistically significant(P<0.05). In the reference group, the total symptom scores at 1 week and 1 month after treatment were not statistically significant when compared with those before treatment(P>0.05). The incidence of adverse reactions in the experimental group was 11.11%, which was lower than 22.22% in the reference group, but the difference was not statistically significant(P>0.05). Conclusion For MS, vestibular habituation training has a more pronounced effect on prevention and treatment compared to scopolamine, resulting in a significant reduction in symptoms without increasing the adverse events in patients.

关 键 词：晕动病 东莨菪碱 前庭习服训练 

分 类 号：R741[医药卫生—神经病学与精神病学]