血清前列腺特异性抗原灰区患者前列腺组织学炎症分级与前列腺病变性质的关系  

Relation between histological inflammation classification of prostate and prostatic lesion nature in patients with serum prostate-specific antigen gray zone

作　　者：冉俊武 王伟[1] 玉铂[1] 杨立 陈翔[1] 卢启海[1] 韦瑶 RAN Junwu;WANG Wei;YU Bo;YANG Li;CHEN Xiang;LU Qihai;Wei Yao(Department of Urology,Liuzhou People′s Hospital Affiliated to Guangxi Medical University,Liuzhou 545000,Guangxi,China;Department of Pathology,Liuzhou People′s Hospital Affiliated to Guangxi Medical University,Liuzhou 545000,Guangxi,China;Department of Traditional Chinese Medicine,Liuzhou Maternal and Child Healthcare Hospital,Liuzhou 545001,Guangxi,China)

机构地区：[1]广西医科大学附属柳州市人民医院泌尿外科,广西柳州市545000 [2]广西医科大学附属柳州市人民医院病理科,广西柳州市545000 [3]柳州市妇幼保健院中医科,广西柳州市545001

出　　处：《广西医学》2023年第1期11-14,共4页Guangxi Medical Journal

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z20180307);广西壮族自治区卫生健康委员会自筹经费科研课题(Z20210340)。

摘　　要：目的探讨血清前列腺特异性抗原(PSA)灰区患者前列腺组织学炎症分级与前列腺病变性质的关系。方法回顾性分析79例行前列腺组织穿刺活检的血清PSA灰区患者的临床资料,根据病理结果分为前列腺良性疾病组58例与前列腺癌组21例。采用前列腺组织学炎症分类系统对患者前列腺组织的炎症解剖学位置、炎症范围及炎症程度进行分级。采用多因素Logistic回归模型分析前列腺组织学炎症分级与前列腺癌的相关性。结果两组患者的前列腺组织炎症范围差异均有统计学意义(P<0.05),而两组患者的前列腺组织炎症解剖学位置、炎症程度差异无统计学意义(均P>0.05)。多因素Logistic回归分析结果显示,年龄、前列腺组织炎症范围、前列腺组织炎症程度与前列腺癌具有相关性(均P<0.05)。结论在血清PSA灰区患者中,前列腺组织学炎症分级中的炎症范围、炎症程度与前列腺癌相关。Objective To investigate the relation between histological inflammation classification of prostate and prostatic lesion nature in patients with serum prostate-specific antigen(PSA)gray zone.Methods The clinical data of 79 patients with serum PSA gray zone who underwent needle biopsy in prostatic tissues were retrospectively analyzed,and they were assigned to prostatic benign disease group(58 cases)or prostatic carcinoma group(21 cases)according to pathological results.Anatomic location,extent and degree of prostatic histological inflammation were graded by the prostatic histological inflammation grading system.The correlation between histological inflammation classification of prostate and prostate cancer was analyzed by the multivariate Logistic regression model.Results There were statistically significant difference in extent of prostatic histological inflammation between the two groups(P<0.05),whereas there was no statistically significant difference in anatomic location,and degree of prostatic histological inflammation between the two groups(all P>0.05).The results of multivariate Logistic regression analysis revealed that age,extent of prostatic histological inflammation,degree of prostatic histological inflammation presented correlations with prostate cancer(all P<0.05).Conclusion The extent and degree in prostatic histological inflammation classifications interpret correlations with prostate cancer in patients with serum PSA gray zone.

关 键 词：前列腺癌 前列腺组织学炎症分级 血清前列腺特异抗原灰区 穿刺活检 

分 类 号：R737.25[医药卫生—肿瘤]