肿瘤相关成纤维细胞在子宫内膜癌中的研究进展  

Reseach Progress of Cancer-Associated Fibroblasts in Endometrial Cancer

作　　者：余志成 汪宏波(审校)[1] YU Zhi-cheng;WANG Hong-bo(Department of Obstetrics and Gynecology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院妇产科,武汉430022

出　　处：《国际妇产科学杂志》2023年第1期16-19,46,共5页Journal of International Obstetrics and Gynecology

摘　　要：肿瘤微环境(tumor microenvironment,TME)中不同类型细胞的相互作用在子宫内膜癌(endometrial cancer)的发生、发展中起到了关键作用。其中肿瘤相关成纤维细胞(cancer-associated fibroblasts,CAFs)作为TME的重要组成部分,通过直接或间接作用的方式调控子宫内膜癌细胞的恶性生物学行为,促进肿瘤进展。研究表明CAFs参与调节子宫内膜癌细胞的增殖、迁移、侵袭和代谢等途径,同时在TME的基质重塑、血管生成和免疫调节等方面发挥着重要作用。以CAFs为靶点的临床试验研究打破了子宫内膜癌传统治疗手段的局限性,为终末期子宫内膜癌患者带来了新的治疗选择,然而仅有部分患者获益,其中CAFs的来源及功能异质性与治疗抵抗密切相关。综述CAFs在子宫内膜癌中的研究进展,以深入了解CAFs的特性及功能,为子宫内膜癌的诊治提供新的思路。The interaction of different types of cells in the tumor microenvironment(TME)plays a key role in the development of endometrial cancer.Among them,cancer-associated fibroblasts(CAFs),as an important component of TME,regulate the malignant bilolgical behavior of endometrial cancer through direct or indirect ways,and promote tumor progression.Studies have shown that CAFs are involved in regulating the pathways of proliferation,migration,invasion and metabolism of endometrial cancer cells,and they also play an important role in the matrix remodeling,angiogenesis and immune regulation of TME.Clinical trials targeting CAFs have broken the limitations of traditional treatments for endometrial cancer and brought new treatment options for patients with end-stage endometrial cancer,but only some patients will benefit.The sources and functional heterogeneity of CAFs are closely related to treatment resistance.This article reviews the research progress of CAFs in endometrial cancer to deeply understand the characteristics and functions of CAFs,so as to provide new ideas for the treatment of endometrial cancer.

关 键 词：子宫内膜肿瘤 癌相关成纤维细胞 肿瘤微环境 新生血管化 病理性 治疗 

分 类 号：R737.33[医药卫生—肿瘤]