铁死亡在蛛网膜下腔出血早期脑损伤发病机制中作用的研究进展  

Recent progress of the role of ferroptosis in the pathogenesis of early brain injury after subarachnoid hemorrhage

作　　者：曲大鹏 孙会艳 李强[3] 王洪权 QU Dapeng;SUN Huiyan;LI Qiang;WANG Hongquan(Department of Emergency Medicine;Department of Neurology,the Affiliated Hospital of Chifeng University,Chifeng 024005;Health Science Center,Chifeng University,Chifeng 024000;Department of Neurology,Aerospace Center Hospital,Aerospace School of Clinical Medicine,Peking University,Beijing 100049,China)

机构地区：[1]赤峰学院附属医院急诊科,内蒙古自治区赤峰024005 [2]赤峰学院附属医院神经内科,内蒙古自治区赤峰024005 [3]赤峰学院医学部,内蒙古自治区赤峰024000 [4]航天中心医院/北京大学航天临床医学院神经内科,北京100049

出　　处：《基础医学与临床》2023年第3期486-489,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(81260196);内蒙古自然科学基金(2020MS08175,2021MS08131,2021LHMS08024);内蒙古自治区高校科研项目(NJZY19218);航天中心医院院级基金(YN202104)。

摘　　要：蛛网膜下腔出血(SAH)导致铁死亡,表现为铁代谢失调、脂质过氧化增加和谷胱甘肽/谷胱甘肽过氧化物酶4(GSH/GPX4)的抑制。铁死亡介导SAH后72小时内早期脑损伤(EBI-SAH)进而导致SAH预后不良。通过药物靶向抑制铁死亡能够减轻EBI-SAH,为未来治疗EBI-SAH提供了新的靶点。Subarachnoid hemorrhage(SAH)leads to ferroptosis with clinical evidence like iron metabolism deregulation,increased lipid peroxitation(LPO)and the inhibition of glutathione/glutathione peroxides 4(GSH/GPX4).Ferroptosis mediated early brain injury(EBI)may occur in the 72-hour period following SAH(EBI-SAH)leads to the poor prognosis of SAH.Pharmacological targeting at ferroptosis mitigate EBI-SAH,provides a new target for future treatment and prevention of EBI-SAH through targeting at ferroptosis.

关 键 词：蛛网膜下腔出血 早期脑损伤 铁死亡 铁死亡抑制剂 

分 类 号：R743.3[医药卫生—神经病学与精神病学]