肠易激综合征生物标志物的研究进展  

Research progress on biomarkers of irritable bowel syndrome

作　　者：郑行健 冉雪 任梓月 戴迟兵[2] ZHENG Xingjian;RAN Xue;REN Ziyue;DAI Chibing(Three Gorges University,Yichang 443002;Renhe Hospital Affiliated to Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学,湖北宜昌443002 [2]三峡大学附属仁和医院,湖北宜昌443002

出　　处：《基础医学与临床》2023年第3期500-504,共5页Basic and Clinical Medicine

基　　金：湖北省卫生健康委科研项目(WJ2021F060)。

摘　　要：肠易激综合征(IBS)是一种功能性胃肠疾病,当前其诊断仍然沿用临床标准。与IBS发病相关的生物标志物有多种,IBS与平均血小板体积(MPV)、红细胞分布宽度(RDW)、中性粒细胞/淋巴细胞比值(NLR)、超敏C反应蛋白(HS-CRP)、C反应蛋白(CRP)、消退素D1(RvD1)、白细胞介素6(IL-6)、白细胞介素8(IL-8)、肿瘤坏死因子-α(TNF-α)、粪钙卫蛋白(FCP)、粪便乳铁蛋白(LF)相关。生物标志物可以减少结肠镜检查的使用,使IBS的诊断更加准确、快捷。Irritable bowel syndrome(IBS)is a functional gastrointestinal disease,and its diagnostic criteria has been based on clinical profile.There are various biomarkers associated with IBS.This paper reviews the relationship between IBS and those biomarkers like mean platelet volume(MPV),red blood cell distribution width(RDW),neutrophil/lymphocyte ratio(NLR),high-sensitivity C-reactive protein(HS-CRP),C-reactive protein(CRP),resolvin D1(RvD1),interleukin 6(IL-6),interleukin 8(IL-8),tumor necrosis factor-α(TNF-α),fecal calprotectin(FCP),fecal lactoferrin(LF).The research and clinical application of valuable biomarkers for the diagnosis of IBS may make the diagnosis of IBS more accurate and faster,with less application of colonoscopy.

关 键 词：肠易激综合征 血清生物标志物 粪便生物标志物 罗马标准 

分 类 号：R574.4[医药卫生—消化系统]