Functional Peptides from One-bead One-compound High-throughput Screening Technique  

作　　者：YAN Yaqiong WANG Lei WANG Hao 

机构地区：[1]CAS Center for Excellence in Nanoscience,CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology(NCNST),Beijing,100190,P.R.China [2]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing,100049,P.R.China

出　　处：《Chemical Research in Chinese Universities》2023年第1期83-91,共9页高等学校化学研究（英文版）

基　　金：supported by the Strategic Priority Research Program of Chinese Academy of Sciences (No.XDB36000000);the National Natural Science Foundation of China (Nos.8201101351,51890891,51890892,51890894).

摘　　要：Combinatorial chemistry provides a cost-effective method for the rapid discovery of new functional peptides.One-bead one-compound(OBOC)high-throughput screening technique offers a lot of structurally diverse peptides to be rapidly synthesized and screened for binding to a target of interest.The OBOC peptide library screening involves three main steps:library construction,positive beads separation,and peptide sequencing.This review mainly summarizes some special technique tips during functional peptide screening and potential future directions of the OBOC high-throughput screening technique.

关 键 词：Combinatorial chemistry One-bead one-compound(OBOC) Cyclic peptide Peptide screening Self-assembly 

分 类 号：R73[医药卫生—肿瘤]