脑组织通道磁示踪成像分析仪的设计与应用  

Design and application of brain tissue channel tracer-based magnetic resonance imaging analyzer

作　　者：王卉 周洁[1,2,3] 成雨萌 王缪天 刘会坡 操江峰[5] 习科 张弘 李楠 牛田野[8] 谢肇恒 张研 薛言学[10] 吕鹏宇[11] 卢嘉宾 徐萌 韩鸿宾 WANG Hui;ZHOU Jie;CHENG Yumeng;WANG Miaotian;LIU Huipo;CAO Jiangfeng;XI Ke;ZHANG Hong;LI Nan;NIU Tianye;XIE Zhaoheng;ZHANG Yan;XUE Yanxue;LÜPengyu;LU Jiabin;XU Meng;HAN Hongbin(Institute of Medical Technology,Peking University Health Science Center,Beijing 100191,China;Department of Radiology,Peking University Third Hospital,Beijing 100191,China;Beijing Key Laboratory of Magnetic Resonance Imaging Devices and Technology,Beijing 100191,China;Institute of Applied Physics and Computational Mathematics,Beijing 100094,China;Institute of Information Engineering,Chinese Academy of Sciences Beijing 100093,China;Shenzhen RF Tech Co.,Ltd.,Shenzhen 518054,China;Research Center of Clinical Epidemiology,Peking University Third Hospital,Beijing 1000191,China;Institute of Biomedical Engineering,Shenzhen Bay Laboratory,Shenzhen 518067,China;State Key Laboratory of Membrane Biology,College of Life Sciences,Peking University,Beijing 100871,China;National Institute on Drug Dependence,Peking University,Beijing 100191,China;State Key Laboratory for Turbulence and Complex Systems,Department of Advanced Manufacturing and Robotics,College of Engineering,Peking University,Beijing 100871,China;Peking University Shenzhen Graduate School,Shenzhen 518055,China)

机构地区：[1]北京大学医学部医学技术研究院,北京100191 [2]北京大学第三医院放射科,北京100191 [3]磁共振成像设备与技术北京市重点实验室,北京100191 [4]北京应用物理与计算数学研究所,北京100094 [5]中国科学院信息工程研究所,北京100093 [6]深圳市特深电气有限公司,深圳518054 [7]北京大学第三医院临床流行病研究中心,北京100191 [8]深圳湾实验室医学工程研究所,深圳518067 [9]膜生物学国家重点实验室,北京大学生命科学学院,北京100871 [10]北京大学中国药物依赖性研究所,北京100191 [11]北京大学工学院先进制造与机器人系,北京100871 [12]北京大学深圳研究生院,深圳518055

出　　处：《磁共振成像》2023年第2期109-115,124,共8页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:61827808);深圳市海外高层次人才“孔雀计划”(编号:KQTD20180412181221912)。

摘　　要：目的基于经典扩散方程建模求解,设计并研制脑组织通道磁示踪成像分析仪。材料与方法建立信号源导入系统,设计多频段射频激发与信号采集单元,开发图像处理、建模计算与可视化模块,集成脑组织通道磁示踪成像分析仪。将12只成年雄性斯普拉-道来氏大鼠随机平均分成两组,分别应用传统磁示踪法技术方案(n=6)与本研究系统方案(n=6)进行探测,计算并比较扩散系数和容积占比等参数,对组织液(interstitial fluid,ISF)引流过程进行可视化。结果该仪器可同步提供鼠脑细胞外间隙(extracellular space,ECS)结构参数及其内分子扩散情况,实现ISF引流途径的全脑示踪。相对于传统技术方案组,本研究系统组扩散系数和容积占比均下降(P均<0.01),且两个测量结果的标准差均减小。结论脑组织通道磁示踪成像分析仪的研发将ECS探测过程标准化、自动化,使得探测结果更加稳定、更趋向于真实水平,为后续兼容电阻抗、化学等多种信息的ECS探测仪器的研发奠定了基础。Objective:To design and develop a brain tissue channel tracer-based magnetic resonance imaging analyzer based on the classical diffusion equation.Materials and Methods:A signal source import system was established.Multi-band radio frequency excitation and signal acquisition units were designed.Image processing,modeling calculation and visualization modules were developed.The tracer-based magnetic resonance imaging analyzer for brain tissue channels was integrated.Twelve adult male Sprague Dawley rats were randomly divided into two groups on average.The traditional(n=6)and the current(n=6)research system scheme were respectively applied for detection.The diffusion coefficient and volume fraction were calculated and compared.The drainage process of interstitial fluid(ISF)was visualized.Results:The instrument can simultaneously provide the structural parameters and the internal molecular diffusion of extracellular space(ECS)in rat brain,and realize the whole brain tracing of the ISF drainage pathway.Compared with the traditional scheme group,both diffusion coefficient and volume fraction decreased(P<0.01).And the standard deviation of the two measurement results decreased.Conclusions:The development of the brain tissue channel tracer-based magnetic resonance imaging analyzer standardizes and automates the ECS detection process,making the detection results more stable and more realistic,laying a foundation for the subsequent research and development of ECS detection instruments compatible with electrical impedance,chemistry and other information.

关 键 词：脑细胞外间隙 磁示踪 组织间液 系统设计 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R-332[医药卫生—诊断学]