Hippo信号通路在结直肠癌中的作用及其机制研究进展  

Advances in understanding of role and mechanism of Hippo signaling pathway in colorectal cancer

作　　者：马伏艳 周喜汉[2] 梁俏 Fu-Yan Ma;Xi-Han Zhou;Qiao Liang(Graduate School of Youjiang Medical College for Nationalities,Baise 533000,Guangxi Zhuang Autonomous Region,China;Department of Gastroenterology,Affiliated Hospital of Youjiang Medical College Nationalities,Baise 533000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]右江民族医学院研究生学院,广西壮族自治区百色市533000 [2]右江民族医学院附属医院消化内科,广西壮族自治区百色市533000

出　　处：《世界华人消化杂志》2023年第1期14-19,共6页World Chinese Journal of Digestology

摘　　要：结直肠癌(colorectal cancer,CRC)是最常见的恶性肿瘤之一,大多数患者预后差.诸多研究已表明Hippo信号通路在CRC的发生、发展中起关键作用,调控CRC细胞增殖、凋亡、侵袭、转移、自噬、代谢重编程、耐药性等过程.现就Hippo信号通路及关键分子在CRC中的表达以及调控CRC的发生发展机制的最新研究进展作一综述.Colorectal cancer(CRC)is one of the most common malignant tumors,and most patients have a poor prognosis.Many studies have shown that the Hippo signaling pathway plays a key role in the occurrence and development of CRC by regulating CRC cell proliferation and apoptosis,tumor invasion and metastasis,autophagy,metabolic reprogramming,drug resistance,and other processes.This article reviews the latest progress in research of the expression of key molecules of the Hippo signaling pathway in CRC as well as the understanding of the mechanism by which this pathway regulates the occurrence and development of CRC.

关 键 词：结直肠癌 Hippo信号通路 Yes相关蛋白 耐药性 预后标志物 

分 类 号：R735.34[医药卫生—肿瘤]