基于脉络学说“孙络-微血管”概念探讨急性心肌梗死再灌注后无再流的防治  

Prevention and Treatment of No-reflow after Reperfusion in Acute Myocardial Infarction Based on the Concept of“Sunluo-microvessel”in the Theory of Collaterals

作　　者：袁国强[1] 常成成 王芳[1] 刘霞 张凤虹 Yuan Guoqiang;Chang Chengcheng;Wang Fang;Liu Xia;Zhang Fenghong(Hebei Yiling Hospital,Hebei,Shijiazhuang 050091,China;不详)

机构地区：[1]河北以岭医院,河北石家庄050091 [2]河北省中医心血管疾病临床医学研究中心,河北石家庄050091

出　　处：《中国中医急症》2023年第2期256-259,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家重点研发计划“中医药现代化研究”重点专项(2017YFC1700500);河北省重点研发计划项目中医药创新专项(223777120D)。

摘　　要：急性心肌梗死再灌注后无再流是目前心血管界的重要难题与热点研究领域。中医脉络学说提出“孙络-微血管”概念,以此作为切入点解析心梗后无再流的病机、治疗原则、辨证分型与组方用药;通络代表药物通心络胶囊在基础研究中显示出对心肌微血管结构和功能的良好保护作用,临床研究证实其在急性心肌梗死患者心肌无再流和再灌注损伤防治方面具有良好效果,为中医药参与急危重症抢救领域提供了有力证据支撑。No-reflow after reperfusion in acute myocardial infarction(AMI)is an important problem and hot research field in cardiovascular field.The theory of collaterals in TCM put forward the concept of“SunluoMicrovessel”,which was used as the breakthrough point to analyze the pathogenesis,treatment principle,syndrome differentiation and prescription of no-reflow after myocardial infarction.Tongxinluo capsule,a representative drug of collateral theory,showed a good protective effect on myocardial microvascular structure and function in basic research.Clinical studies have proved that it has a good effect on the prevention and treatment of myocardial noreflow and reperfusion injury in patients with AMI,which provides strong evidence support for Chinese medicine to participate in the field of emergency rescue.

关 键 词：急性心肌梗死 脉络学说 孙络-微血管 无再流 

分 类 号：R541.4[医药卫生—心血管疾病]