细胞外信号调节激酶1/2信号通路调控细胞侵袭性的研究进展  

Extracellular Signal-regulated Kinase 1/2 Signaling Regulates Cell Invasion:a Review

作　　者：葛新滢 邵露露 高雪林 何荣霞[1] GE Xinying;SHAO Lulu;GAO Xuelin;HE Rongxia(Obstetrics Department of Lanzhou University Second Hospital,The Second Clinical Medical College of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二临床医学院、兰州大学第二医院产科,兰州730030

出　　处：《中国医学科学院学报》2023年第1期155-160,共6页Acta Academiae Medicinae Sinicae

摘　　要：细胞外信号调节激酶(ERK)1/2是一种蛋白丝氨酸/苏氨酸激酶,参与Ras-Raf有丝分裂原激活蛋白激酶-ERK的信号转导级联,通过影响基因的转录和表达,参与细胞的生长、增殖甚至侵袭作用。肺癌、肝癌、卵巢癌、宫颈癌、子宫内膜异位症及子痫前期等多种疾病的发生,以及其疾病的转移和病情的进展,均与ERK1/2信号通路调控细胞侵袭性密切相关。因此通过探索ERK1/2信号通路侵袭性在相关疾病发病过程中可能发挥的重要作用,从而寻找更加有效的治疗方案。本文根据近些年国内外的最新研究,介绍ERK1/2信号通路侵袭性这一特性在各个疾病中所发挥的相关调控作用,以期为相关疾病的临床治疗研究提供新启示。Extracellular signal-regulated kinase 1/2(ERK1/2)is a serine/threoninekinase involved in the signal transduction cascade of Ras-Raf-mitogen-activated protein kinase(MEK)-ERK.It participates in the cell growth,proliferation and even invasion by regulating gene transcription and expression.The occurrence of a variety of diseases such as lung cancer,liver cancer,ovarian cancer,cervical cancer,endometriosis,and preeclampsia,as well the metastasis and disease progression,is closely associated with the regulation of cell invasion by ERK1/2 signaling pathway.Therefore,exploring the regulation of ERK1/2 signaling on cell invasion and its role in pathogenesis of diseases may help to develop more effective treatment schemes.This article introduces recent progress in the regulation of ERK1/2 signaling on cell invasion and the role of such regulation in diseases,with a view to give new insights into the clinical treatment of ERK 1/2-related diseases.

关 键 词：细胞外信号调节激酶1/2 侵袭性 肿瘤 子痫前期 

分 类 号：R73-37[医药卫生—肿瘤] R714.2[医药卫生—临床医学]