后部葡萄膜黑色素瘤活检及其临床意义的研究  

Study on the clinical significance of posterior uveal melanoma biopsy

作　　者：孙浩 杨会 李姣[4] SUN Hao;YANG Hui;LI Jiao(Medical School of Ophthalmology and Optometry of Shandong University of Traditional Chinese Medicine,Jinan 250002,Shandong,China;Department of Ophthalmology,Lanling People's Hospital of Linyi City,Linyi 276000,Shandong,China;Department of Pathology,The Second Affiliated Hospital of Shandong First Medical University,Taian 271000,Shandong,China;Eye Hospital Affiliated to Shandong University of Traditional Chinese Medicine/Shandong Institute of Eye Disease Control,Jinan 250002,Shandong,China)

机构地区：[1]山东中医药大学眼科与视光医学院,山东济南250002 [2]兰陵县人民医院眼科,山东临沂276000 [3]山东第一医科大学第二附属医院病理科,山东泰安271000 [4]山东中医药大学附属眼科医院/山东省眼病防治研究院,山东济南250002

出　　处：《山东大学耳鼻喉眼学报》2023年第1期152-156,共5页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：山东省医药卫生科技发展计划项目(2018ws194);山东省自然科学基金面上项目(ZR2020MH393)。

摘　　要：后部葡萄膜黑色素瘤(PUMs)是一种最常见的成人眼内原发恶性肿瘤,早期起病隐匿,无典型症状,国内外对于PUMs患者的诊断多以临床特征为依据,容易漏诊或误诊。近年来肿瘤学者对于PUMs患者的确诊(国外确诊也主要依据临床特征,活检主要用于判断预后和进一步研究)常用细针穿刺活检(FNAB)和玻璃体视网膜脉络膜活检(TVRC)两种活检方式。目前关于FNAB、TVRC用于确诊PUMs患者的系统性总结研究较少,故本文就两种活检方式用于PUMs患者确诊时的临床安全性、取样方法、临床意义等展开综述。Posterior uveal melanoma(PUMs), the most common primary intraocular malignant tumor in adults, typically has an early onset that is insidious and asymptomatic. The diagnosis of patients with PUMs at home and abroad is primarily based on clinical features, which are easily missed or misdiagnosed. In recent years, oncologists have commonly used two types of biopsies to confirm the diagnosis of patients with PUMs: fine-needle aspiration biopsy(FNAB) and transvitreal retinochoroidal biopsy(TVRC). At present, there are few systematic studies on the application of FNAB and TVRC in the diagnosis of PUM. This paper reviews the clinical safety, sampling methods, and clinical significance of these two biopsy methods in the diagnosis of PUM.

关 键 词：后部葡萄膜黑色素瘤 细针穿刺活检 玻璃体视网膜脉络膜活检 安全性 临床意义 

分 类 号：R779.62[医药卫生—眼科]