自身免疫性肝炎研究进展  

Research advances on autoimmune hepatitis

作　　者：路遥 孙芳芳 曾湛 邓雯 蒋婷婷 刘如玉 Lu Yao;Sun Fangfang;Zeng Zhan;Deng Wen;Jiang Tingting;Liu Ruyu(Department of Hepatology Division 2,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京地坛医院肝病二科,北京100015

出　　处：《中国肝脏病杂志（电子版）》2022年第4期1-9,共9页Chinese Journal of Liver Diseases：Electronic Version

基　　金：国家科技重大专项(2017ZX10201201-001-006、2017ZX10201201-002-006、2018ZX10715-005-003-005);北京市科学技术委员会首都临床诊疗技术研究及示范应用项目(Z191100006619052);北京市医管中心培育计划(PX2018060);北京市医管中心青苗计划(QML20181803);北京市医管中心消化协同中心资助项目(XXZ0302、XXT28);北京市医管中心临床专项项目(XMLX201706、XMLX202127);北京市科委课题(D161100002716002);首都临床特色专项资助项目(Z151100004015122);首都卫生发展专项公共卫生项目(2021-1G-4061)。

摘　　要：自身免疫性肝炎(autoimmune hepatitis,AIH)是一种坏死性炎症性肝病,为针对肝细胞的自身免疫反应所介导的肝脏实质炎症,以血清自身抗体阳性、高免疫球蛋白G和(或)γ球蛋白血症、肝组织学上存在界面性肝炎为特点,如不治疗常可导致肝硬化、肝衰竭。近年来,我国AIH发病率呈逐年升高趋势,逐渐成为除病毒性肝炎外影响我国人民身体健康的重要肝病之一,现将AIH的流行病学、发病机制、临床特点及诊疗方案进行综述。Autoimmune hepatitis(AIH)is a necrotizing inflammatory liver disease,which is mediated by the autoimmune response to liver cells,and is characterized by positive serum autoantibodies,high immunoglobulin G and(or)γglobulinemia,and the presence of interfacial hepatitis on liver histology.If left untreated,it can lead to liver cirrhosis and liver failure.In recent years,the morbidity of AIH in China has been increasing year by year,and it has gradually become one of the important liver diseases affecting the health of Chinese people except viral hepatitis.In this article,the epidemiology,pathogenesis,clinical characteristics and diagnosis and treatment plan of AIH were reviewed.

关 键 词：自身免疫性肝炎 发病机制 临床特点 诊疗方案 

分 类 号：R575.1[医药卫生—消化系统]