血清人附睾蛋白4对非小细胞肺癌的诊断价值  

Diagnosis value of serum human eididymis 4 in the non-small cell lung cancer

作　　者：王子搏畅 陈婷婷 连亨宁 汪璐 田德兴 胡绳 曲远清 黄小露 马李杰 肖贞良 WANG Zibochang;CHEN Tingting;LIAN Hengning;WANG Lu;TIAN Dexing;HU Sheng;QU Yuanqing;HUANG Xiaolu;MALijie;XIAO Zhenliang(Department of Pulmonary and Critical Care Medicine,General Hospital of Western Theater Command,Chengdu 610083,Sichuan,China;Department of Basic Faulty,Engineering University of Chinese Armed Police Force,Xi’an 710086,Shaanxi,China;Department of Clinical Laboratory,General Hospital of Western Theater Command,Chengdu 610083,Sichuan,China)

机构地区：[1]西部战区总医院呼吸与危重症医学科,成都610083 [2]武装警察部队工程大学基础部,西安7100860 [3]西部战区总医院检验科,成都610083

出　　处：《癌症进展》2023年第2期162-165,168,共5页Oncology Progress

基　　金：中国博士后科学基金(2018M643895)。

摘　　要：目的探讨人附睾蛋白4(HE4)在非小细胞肺癌(NSCLC)患者血清中的表达及在NSCLC诊断中的价值。方法选取97例NSCLC患者作为肺癌组,47例健康体检人群作为对照组。测定所有研究对象血清HE4、癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原19-9(CA19-9)水平,评价其对肺癌的诊断效能。结果肺癌组患者血清HE4、CEA、CA19-9、CA125水平均明显高于对照组,差异均有统计学意义(P﹤0.01)。男性NSCLC患者血清HE4水平高于女性患者,差异有统计学意义(P﹤0.05)。有远处转移的NSCLC患者血清HE4、CEA、CA19-9、CA125水平均明显高于无远处转移患者,差异均有统计学意义(P﹤0.01)。受试者工作特征(ROC)曲线分析显示,HE4联合CEA或CA125检测诊断肺癌的曲线下面积(AUC)均大于HE4单独检测,联合检测对肺癌诊断有较高的特异度。结论HE4对肺癌有一定的辅助诊断价值,与CA125或CEA联合检测对NSCLC诊断的特异度高于HE4单独检测,可提高肺癌的诊断率,具有较高的临床应用价值。Objective To investigate the expression and diagnostic value of serum human eididymis 4(HE4)in nonsmall cell lung cancer(NSCLC)patients.Method A total of 97 NSCLC patients were selected into the lung cancer group,and 47 healthy subjects into the control group.Serum HE4,carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and carbohydrate antigen 19-9(CA19-9)were measured to evaluate the diagnostic value for lung cancer.Result The levels of HE4,CEA,CA19-9 and CA125 in the lung cancer group were significantly higher than those in the control group(P<0.01);the serum HE4 of male patients in lung cancer group was significantly higher than that of female patients(P<0.05);the serum HE4,CEA,CA19-9 and CA125 in patients with distant metastasis were significantly higher than those in patients without distant metastasis(P<0.01).Receiver operator characteristic(ROC)curve analysis showed that the area under the curve(AUC)of HE4 combined with CEA or CA125 were larger than that of HE4 in the diagnosis of lung cancer,and the combined detection has high specificity for diagnosis of lung cancer.Conclusion HE4 has a certain value in the auxiliary diagnosis of lung cancer.The specificity of HE4 combined detection with CA125 or CEA in the diagnosis of NSCLC is much higher than HE4 detection,which may improve the diagnosis rate of lung cancer and has higher clinical application value.

关 键 词：非小细胞肺癌 人附睾蛋白4 癌胚抗原 糖类抗原125 

分 类 号：R734.2[医药卫生—肿瘤]