血小板抗体检测在地中海贫血治疗中的应用研究  

Application of platelet antibody detection in the treatment of thalassemia

作　　者：陈瑞明 熊敏 肖颖 廖良兴 张红 郭芬红 CHEN Ruiming;XIONG Min;XIAO Ying;LIAO Liangxing;ZHANG Hong;GUO Fenhong(Ganzhou Maternal and Child Health Hospital,Ganzhou 341000 China)

机构地区：[1]赣州市妇幼保健院,江西赣州341000

出　　处：《临床医药实践》2023年第3期173-177,共5页Proceeding of Clinical Medicine

基　　金：江西省卫生健康委员会科技计划项目(项目编号:20204663)。

摘　　要：目的:探讨血小板抗体检测在地中海贫血(以下简称地贫)治疗中的应用价值。方法:将2019年11月—2020年11月收治的45例地贫患者作为对照组,2020年12月—2021年12月收治的99例地贫患者作为观察组,两组均接受反复输注去白红细胞悬液治疗,对照组直接给予对症治疗,观察组于治疗前测定血小板抗体情况,随后进行对症治疗。比较两组患者治疗后非溶血性发热反应(NHFTR)发生率,分析观察组患者NHFTR发生的影响因素,分析其对NHFTR发生的预测价值。结果:观察组NHFTR发生率低于对照组(P<0.05)。单因素与二元Logistic回归分析结果显示血小板抗体测定结果、贫血程度是观察组患者NHFTR发生的影响因素(P<0.05)。受试者工作特征曲线显示,观察组患者血小板抗体测定结果、贫血程度用于预测NHFTR发生的曲线下面积分别为0.856和0.763。结论:血小板抗体以及贫血程度是地贫患者NHFTR发生的影响因素,患者去白红细胞悬液治疗前行血小板抗体检测有助于减少NHFTR发生。Objective: To explore the application value of platelet antibody detection in the treatment of thalassemia.Methods: This study included 45 patients with thalassemia(control group) admitted to the hospital from November 2019 to November 2020,and 99 patients with thalassemia(observation group) admitted to the hospital from December 2020 to December 2021.Both groups were treated with repeated infusion of leukocyte-depleted red blood cell suspension.Patients in the control group were given symptomatic treatment, and patients in the observation group were given symptomatic treatment after platelet antibody detection.The incidence of non-hemolytic febrile transfusion reactions(NHFTR) after treatment was compared between the two groups.The factors affecting the occurrence of NHFTR in observation group, and their predictive value for NHFTR were analyzed.Results: The incidence of NHFTR in observation group was lower than that in control group(P<0.05).Univariate analysis and binary logistic regression analysis showed that detection results of platelet antibodies and anemia degree were the influencing factors of NHFTR in observation group(P<0.05).The receiver operating characteristic curve showed that the areas under the curve of detection results of platelet antibodies and anemia degree to predict NHFTR were 0.856 and 0.763.Conclusion: Platelet antibodies and anemia degree are the influencing factors of NHFTR in patients with thalassaemia.The detection of platelet antibodies before the treatment with leukocyte-depleted red blood cell suspension can help reduce the incidence of NHFTR.

关 键 词：血小板抗体 地中海贫血 贫血程度 非溶血性发热反应 

分 类 号：R552[医药卫生—血液循环系统疾病]