紫杉醇+顺铂化疗同步放疗与序贯化放疗治疗局部晚期鼻咽癌的临床分析及对患者生活质量的影响  

Clinical Analysis of Paclitaxel + Cisplatin Chemotherapy Concurrent Radiotherapy and Sequential Chemoradiotherapy in the Treatment of Locally Advanced Nasopharyngeal Carcinoma and Its Impact on Patients’ Quality of Life

作　　者：叶兴发 吴传高 刘晓青 董柱清 YE Xingfa;WU Chuangao;LIU Xiaoqing;DONG Zhuqing(Department of Radiotherapy,Ningde Mindong Hospital,Ningde,Fujian Province,355000 China)

机构地区：[1]宁德市闽东医院放疗科,福建宁德355000

出　　处：《中外医疗》2022年第30期17-21,共5页China & Foreign Medical Treatment

摘　　要：目的 紫杉醇+顺铂化疗同步放疗与序贯化放疗治疗局部晚期鼻咽癌的临床观察及对患者生活质量的影响。方法 2018年6月—2021年4月期间在宁德市闽东医随机选取60例晚期鼻咽癌患者,将其进行随机抽签并平均分为对照组(序贯化放疗)和研究组(同步放化疗),每组30例,观察两组患者的不良反应、生活质量、疗效、心理状态和疼痛评分等情况。结果 研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组生活质量评分比对照组高,差异有统计学意义(P<0.05)。研究组的治疗有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,研究组情绪评分(SDS评分、SAS评分)和对照组相比,差异无统计学意义(P>0.05);治疗后,研究组患者SDS评分(23.3±2.2)分、SAS评分(23.1±3.1)分低于对照组SDS评分(35.5±3.6)分、SAS评分(35.5±3.4)分,差异有统计学意义(t=15.838、14.761,P<0.05)。两组患者治疗前疼痛评分对比,差异无统计学意义(P>0.05);研究组在治疗后疼痛评分显著低于对照组,差异有统计学意义(P<0.05)。结论 在临床治疗上采用同步放化疗的方法,患者的生活质量明显提高,治疗后患者恢复的速度快,治疗效果较好。Objective To observe the clinical observation of paclitaxel + cisplatin chemotherapy with concurrent radiotherapy and sequential chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma and its impact on the quality of life of patients. Methods 60 patients with advanced nasopharyngeal carcinoma were randomly selected in the Mindong Hospital of Ningde City from June 2018 to April 2021, who were randomly drawn and divided into the control group(treatment with sequential chemoradiotherapy) and the study group(treatment with concurrent chemoradiotherapy), 30 cases in each group, and the adverse reactions, quality of life, curative effect, psychological state and pain score of the two groups of patients were observed. Results The incidence of adverse reactions in the study group was lower than that in the control group, the difference was statistically significant(P<0.05). The quality of life score in the study group was higher than that in the control group, the difference was statistically significant(P<0.05). The treatment efficiency of the study group was higher than that in the control group, the difference was statistically significant(P<0.05). Before treatment, there was no statistically significant difference in the mood scores(SDS,SAS) and between the study group and the control group(P>0.05);after treatment, the SDS score(23.3±2.2) points,SAS score(23.1±3.1) points of the study group were lower than the SDS score(35.5±3.6) points, SAS score(35.5±3.4) points of the control group, the difference was statistically significant(t=15.838, 14.761, P<0.05). There was no statistically significant difference in the pain scores between the two groups before treatment(P>0.05);and the pain scores in the study group were significantly lower than those in the control group after treatment, the difference was statistically significant(P<0.05). Conclusion Concurrent chemoradiotherapy is used in clinical treatment, the quality of life of patients is significantly improved, the recovery speed of pati

关 键 词：同步放化疗 序贯化放疗 局部晚期鼻咽癌 生活质量 

分 类 号：R739[医药卫生—肿瘤]