桑色素缓解肾脏损伤的药理学机制研究进展  

Progress in Research on Pharmacological Mechanism of Morin in Alleviating Renal Injury

作　　者：李世杰 杜宇凡 万子彦 王婉如 张冬梅[1] LI Shi-jie;DU Yu-fan;WAN Zi-yan;WANG Wan-ru;ZHANG Dong-mei(School of Life Science,Nanjing University,Nanjing 210023,China)

机构地区：[1]南京大学生命科学学院,南京210023

出　　处：《中国药学杂志》2023年第1期18-25,共8页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(81973374,81673488)。

摘　　要：桑色素是来源于桑科植物的一种天然吡喃环黄酮类生物活性化合物。桑枝、桑叶、桑白皮等桑来源中草药是中国传统中药,常出现在治疗肾损伤相关疾病的药方中。已有动物和体外实验表明,桑色素具有抗氧化、抗炎、调控细胞凋亡和异常增殖等广泛的药理学活性,在缓解糖尿病、痛风、关节炎及高血压等疾病中极具潜力。同时,大量研究发现,桑色素可通过多种机制发挥其对肾损伤疾病的缓解作用,值得深入探索。笔者围绕桑色素缓解肾损伤的药理学机制研究进行综述与分析,为相关研究提供参考。尽管桑色素缓解肾损伤的药理学活性已在动物和体外实验中被证明,但目前还存在生物利用度低,临床研究开展较少等问题,未来还需要更多的研究,以期最终实现桑色素的临床应用。Morin is a kind of natural pyran ring flavonoid from Moraceae plants.Mulberry branches,mulberry leaves,white mulberry root barks and other mulberry-derived herbs are traditional Chinese medicines,which often appear in the prescriptions for treatment of kidney injury-related diseases.Animal experiments and in vitro experiments have shown that morin has a wide range of pharmacological activities,such as antioxidant,anti-inflammatory,regulation of cell apoptosis and aberrant proliferation,and has great potential in alleviating diseases such as diabetes,gout,arthritis and hypertension.At the same time,a large number of studies have shown that morin can alleviate kidney injury diseases through a variety of mechanisms,which is worth further exploration.In this review,the mechanism of morin in alleviating kidney injury is expounded and analyzed to provide reference for related studies.Although the pharmacological activity of morin in alleviating kidney injury has been demonstrated in animals and in vitro experiments,there are still problems of low bioavailability,few clinical studies,and so on.More studies are needed in order to achieve the clinical application of morin.

关 键 词：桑色素 肾损伤 尿酸代谢 抗氧化 抗炎 细胞凋亡 细胞自噬 细胞增殖 能量代谢 

分 类 号：R285.5[医药卫生—中药学]