Clostridioides difficile infection in patients with nonalcoholic fatty liver disease-current status  

作　　者：Yana V Kiseleva Roman V Maslennikov Aida N Gadzhiakhmedova Tatyana S Zharikova Dmitry V Kalinin Yury O Zharikov 

机构地区：[1]International School“Medicine of the Future”,I.M.Sechenov First Moscow State Medical University(Sechenov University),Moscow 119991,Russia [2]Department of Internal Medicine,Gastroenterology and Hepatology,I.M.Sechenov First Moscow State Medical University(Sechenov University),Moscow 119435,Russia [3]Department of Internal Medicine,Сonsultative and Diagnostic Center No.2,Moscow City Health Department,Moscow 107564,Russia [4]Department of Human Anatomy and Histology,I.M.Sechenov First Moscow State Medical University(Sechenov University),Moscow 125009,Russia [5]Department of Pathology,A.V.Vishnevsky National Medical Research Center of Surgery,Moscow 115093,Russia

出　　处：《World Journal of Hepatology》2023年第2期208-215,共8页世界肝病学杂志（英文版）（电子版）

摘　　要：Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disease,leading to fibrosis,cirrhosis and hepatocellular carcinoma and also associated with increased cardiovascular disease mortality.The pathogenesis of NAFLD is not fully understood,although NAFLD is thought to be a hepatic form of metabolic syndrome.There is an increasing understanding of the role of microbiota disturbances in NAFLD pathogenesis,and as with many other conditions affecting the microbiota,NAFLD may be a novel risk factor for Clostridioides difficile(C.difficile)colonization(CDC)and C.difficile infection(CDI).CDI is an emerging nosocomial disease,and community-acquired cases of infection are growing,probably due to an increase in CDC rates.The association of NAFLD with CDI has been shown in only 4 studies to date,three of which included less than 1000 patients,although the frequency of NAFLD in these studies was observed in almost 20%of the total patient cohort.These data revealed that NAFLD is a risk factor for CDI development and,moreover,is a risk factor for intestinal complications of CDI.More studies are needed to investigate this association and move forward CDC and CDI screening efforts for this group of patients.

关 键 词：Nonalcoholic fatty liver disease Clostridioides difficile Clostridioides difficile colonization Clostridioides difficile infection Minireview 

分 类 号：R575.5[医药卫生—消化系统]