Sonographic gallbladder wall thickness measurement and the prediction of esophageal varices among cirrhotics  

作　　者：Mohamed H Emara Mariam Zaghloul Ibrahim F Amer Aya M Mahros Mohammed Hussien Ahmed Mahmoud A Elkerdawy Eslam Elshenawy Abdelrahman M Ahmed Rasheda Tarik I Zaher Mona Talaat Haseeb Emad Hassan Emara Hassan Elbatae 

机构地区：[1]Department of Hepatology,Gastroenterology and Infectious Diseases,Kafrelsheikh University,Kafr-Elshikh 33516,Egypt [2]Department of Internal Medicine,Gastroenterology Unit,Security Forces Hospital,Riyadh 11481,Saudi Arabia [3]Tropical Medicine,Zagazig University,Zagazig 44519,Egypt [4]Department of Diagnostic and Interventional Radiology,Kafrelsheikh University,Kafr-Elshikh 33516,Egypt

出　　处：《World Journal of Hepatology》2023年第2期216-224,共9页世界肝病学杂志（英文版）（电子版）

摘　　要：Acute variceal bleeding in patients with liver cirrhosis and portal hypertension(PHT) is the most serious emergency complication among those patients and could have catastrophic outcomes if not timely managed. Early screening by esophago-gastro-duodenoscopy(EGD) for the presence of esophageal varices(EVs) is currently recommended by the practice guidelines for all cirrhotic patients. Meanwhile, EGD is not readily accepted or preferred by many patients. The literature is rich in studies to investigate and validate non-invasive markers of EVs prediction aiming at reducing the unneeded endoscopic procedures. Gallbladder(GB) wall thickness(GBWT) measurement has been found promising in many published research articles. We aim to highlight the validity of sonographic GBWT measurement in the prediction of EVs based on the available evidence. We searched databases including Cochrane library, Pub Med, Web of Science and many others for relevant articles. GBWT is associated with the presence of EVs in cirrhotic patients with PHT of different etiologies. The cut-off of GBWT that can predict the presence of EVs varied in the literature and ranges from 3.1 mm to 4.35 mm with variable sensitivities of 46%-90.9% and lower cutoffs in viral cirrhosis compared to non-viral, however GBWT > 4 mm in many studies is associated with acceptable sensitivity up to 90%. Furthermore, a relation was also noticed with the degree of varices and portal hypertensive gastropathy.Among cirrhotics, GBWT > 3.5 mm predicts the presence of advanced(grade Ⅲ-Ⅳ) EVs with a sensitivity of 45%, the sensitivity increased to 92% when a cut-off ≥ 3.95 mm was used in another cohort. Analysis of these results should carefully be revised in the context of ascites, hypoalbuminemia and other intrinsic GB diseases among cirrhotic patients. The sensitivity for prediction of EVs improved upon combining GBWT measurement with other non-invasive predictors, e.g., platelets/GBWT.

关 键 词：SONOGRAPHIC Gallbladder wall thickness PREDICTION Esophageal varices Portal hypertension Esophago-gastro-duodenoscopy 

分 类 号：R575.2[医药卫生—消化系统]