Racial and gender-based disparities and trends in common psychiatric conditions in liver cirrhosis hospitalizations:A ten-year United States study  

作　　者：Pratik Patel Hassam Ali Faisal Inayat Rahul Pamarthy Alexa Giammarino Fariha Ilyas Lucia Angela Smith-Martinez Sanjaya K Satapathy 

机构地区：[1]Department of Gastroenterology,Mather Hospital and Hofstra University Zucker School of Medicine,Port Jefferson,NY 11777,United States [2]Department of Internal Medicine,East Carolina University Brody School of Medicine,Greenville,NC 27834,United States [3]Department of Internal Medicine,Allama Iqbal Medical College,Lahore 54550,Punjab,Pakistan [4]Department of Internal Medicine,North Shore University Hospital and Hofstra University Zucker School of Medicine,Port Jefferson,NY 11777,United States [5]Department of Psychiatry,East Carolina University Brody School of Medicine,Greenville,NC 27834,United States [6]Department of Hepatology,North Shore University Hospital and Hofstra University Zucker School of Medicine,Manhasset,NY 11030,United States

出　　处：《World Journal of Hepatology》2023年第2期289-302,共14页世界肝病学杂志（英文版）（电子版）

摘　　要：BACKGROUND Chronic liver disease is associated with various neuropsychiatric conditions.There are currently no large studies assessing and comparing the prevalence of psy-chiatric illnesses based on patient profiles and the etiology of cirrhosis.AIM To examine the trends of hospitalizations among psychiatric conditions in cirrhosis.METHODS We used the National Inpatient Sample database 2016-2019 for the primary diagnosis of liver cirrhosis.The outcomes included the prevalence,trends,and associations of psychiatric diagnoses in these hospitalizations.Chi-square for categorical variables and the Wilcoxon rank test for continuous variables were utilized.RESULTS The prevalence of generalized anxiety disorder(GAD)in liver cirrhosis hospitalizations increased from 0.17%in 2009 to 0.92%in 2019(P<0.001).The prevalence of depression increased from 7%in 2009 to 12%in 2019(P<0.001).Attention deficit hyperactivity disorder(ADHD)prevalence increased from 0.06%to 0.24%.The prevalence of schizophrenia increased from 0.59%to 0.87%(P<0.001).Schizoaffective disorder prevalence increased from 0.10%to 0.35%(P<0.001).Posttraumatic stress disorder(PTSD)prevalence displayed increasing trends from 0.36%in 2009 to 0.93%in 2019(P<0.001).The prevalence of suicidal ideation increased from 0.23%to 0.56%in 2019.Cirrhosis related to alcoholic liver disease[adjusted odds ratios(aOR)1.18,95%CI 1.08-1.29,P<0.001]and non-alcoholic fatty liver disease(NAFLD)(aOR 1.14,95%CI 1.01-1.28,P=0.025)was associated with depression more than other causes.Alcohol-and NAFLD-associated cirrhosis had a stronger link to psychiatric disorders.Females had a higher association with GAD(aOR 2.56,95%CI 2.14-3.06,P<0.001),depression(aOR 1.78,95%CI 1.71-1.84,P<0.001),bipolar disorder(aOR 1.64,95%CI 1.52-1.77,P<0.001]and chronic fatigue(aOR 2.31,95%CI 1.31-4.07,P<0.001)when compared to males.Blacks,Hispanics,and Asian/Native Americans had a significantly lower association with GAD,depression,bipolar disorder,PTSD,and ADHD when compared to the white race.CONCLUSION The pre

关 键 词：Liver cirrhosis hospitalizations Psychiatric conditions Racial and gender disparities 

分 类 号：R575.2[医药卫生—消化系统]