Autoimmune hepatitis and eosinophilia:A rare case report  

作　　者：Isabel Garrido Susana Lopes Elsa Fonseca Fátima Carneiro Guilherme Macedo 

机构地区：[1]Department of Gastroenterology and Hepatology,Centro Hospitalar Universitário de São João,World Gastroenterology Organization Porto Training Center,Faculty of Medicine of the University of Porto,Porto,Portugal [2]Department of Pathology,Centro Hospitalar Universitário de São João,Instituto de Investigação e Inovação em Saúde(i3S)and Institute of Molecular Pathology and Immunology,University of Porto(Ipatimup),Faculty of Medicine of the University of Porto,Porto,Portugal

出　　处：《World Journal of Hepatology》2023年第2期311-317,共7页世界肝病学杂志（英文版）（电子版）

摘　　要：BACKGROUND Autoimmune hepatitis consists of a chronic liver disease whose etiology is unknown.It is comprised of relevant immunological aspects and of immunemediated liver injury.Eosinophilia may be a considerable feature,particularly happening in male patients.CASE SUMMARY We report here a Crohn´s disease patient presenting with de novo hypergammaglobulinemia,circulating autoantibodies and elevated transaminase levels.He also had significant peripheral eosinophilia and elevated immunoglobulin E levels at diagnosis.The pathology findings from liver biopsy were compatible with autoimmune hepatitis with eosinophilic infiltration.CONCLUSION This is the first report of autoimmune hepatitis with exuberant eosinophilic infiltration in the liver and bone marrow,described in a patient with Crohn’s disease.

关 键 词：Autoimmune hepatitis EOSINOPHILIA Bone marrow Crohn’s disease Case report 

分 类 号：R575[医药卫生—消化系统]