Current therapeutic modalities and chemopreventive role of natural products in liver cancer:Progress and promise  

作　　者：Amit Kumar Singh Shiv Vardan Singh Ramesh Kumar Shashank Kumar Sabyasachi Senapati Abhay K Pandey 

机构地区：[1]Department of Botany,Government Naveen Girls College,Balod(Hemchand Yadav University),Durg,Chattisgarh,India [2]Department of Biochemistry,University of Allahabad,Prayagraj 211002,Uttar Pradesh,India [3]Department of Biochemistry,School of Basic and Applied Sciences,Central University of Punjab,Bathinda 151401,Punjab,India [4]Department of Human Genetics and Molecular Medicine,Central University of Punjab,Bathinda 151401,Punjab,India

出　　处：《World Journal of Hepatology》2023年第1期1-18,共18页世界肝病学杂志（英文版）（电子版）

摘　　要：Liver cancer is a severe concern for public health officials since the clinical cases are increasing each year,with an estimated 5-year survival rate of 30%–35%after diagnosis.Hepatocellular carcinoma(HCC)constitutes a significant subtype of liver cancer(approximate75%)and is considered primary liver cancer.Treatment for liver cancer mainly depends on the stage of its progression,where surgery including,hepatectomy and liver transplantation,and ablation and radiotherapy are the prime choice.For advanced liver cancer,various drugs and immunotherapy are used as first-line treatment,whereas second-line treatment includes chemotherapeutic drugs from natural and synthetic origins.Sorafenib and lenvatinib are first-line therapies,while regorafenib and ramucirumab are secondline therapy.Various metabolic and signaling pathways such as Notch,JAK/STAT,Hippo,TGF-β,and Wnt have played a critical role during HCC progression.Dysbiosis has also been implicated in liver cancer.Drug-induced toxicity is a key obstacle in the treatment of liver cancer,necessitating the development of effective and safe medications,with natural compounds such as resveratrol,curcumin,diallyl sulfide,and others emerging as promising anticancer agents.This review highlights the current status of liver cancer research,signaling pathways,therapeutic targets,current treatment strategies and the chemopreventive role of various natural products in managing liver cancer.

关 键 词：Liver cancer Hepatocellular carcinoma Signaling pathways Therapeutic targets Natural products CHEMOPREVENTIVE 

分 类 号：R73[医药卫生—肿瘤]