Successful treatment of granulomatosis with polyangiitis using tocilizumab combined with glucocorticoids:A case report  

作　　者：Peng-Fang Tang Long-Chuan Xu Wen-Ting Hong Hong-Ying Shi 

机构地区：[1]Department of Rheumatology,Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,Fujian Province,China [2]Department of Pathology,Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,Fujian Province,China [3]Department of Immunology,Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,Fujian Province,China

出　　处：《World Journal of Clinical Cases》2023年第5期1144-1151,共8页世界临床病例杂志

摘　　要：BACKGROUND Tocilizumab is a humanized monoclonal antibody against the interleukin-6(IL-6)receptor that is commonly used to treat large vessel vasculitis and antineutrophil cytoplasmic antibody-related small vessel vasculitis.However,tocilizumab in combination with glucocorticoids for successfully treating granulomatosis with polyangiitis(GPA)has rarely been reported.CASE SUMMARY Here,we report a 40-year-old male patient who suffered GPA for 4 years.He was treated with multiple rounds of drugs,including cyclophosphamide,Tripterygium wilfordii,mycophenolate mofetil,and belimumab,with no improvement.In addition,he exhibited persistently high IL-6 levels.After tocilizumab treatment,his symptoms improved,and his inflammatory marker levels returned to normal.CONCLUSION Tocilizumab may be effective for treating GPA.

关 键 词：TOCILIZUMAB Granulomatosis with polyangiitis Antineutrophil cytoplasmic antibody Case report 

分 类 号：R593.2[医药卫生—内科学]