Acute pancreatitis as initial presentation of acute myeloid leukemia-M2 subtype:A case report  

作　　者：Wen-Xin Yang Kang An Gai-Fang Liu Heng-Yu Zhou Jun-Cha Gao 

机构地区：[1]Department of Gastroenterology,Hebei General Hospital,Shijiazhuang 050057,Hebei Province,China [2]Graduate School,Hebei Medical University,Shijiazhuang 050013,Hebei Province,China [3]Graduate School,North China University of Science and Technology,Tangshan 063509,Hebei Province,China

出　　处：《World Journal of Clinical Cases》2023年第6期1385-1392,共8页世界临床病例杂志

摘　　要：BACKGROUND Direct infiltration of the pancreas by acute myeloid leukemia(AML)with acute pancreatitis(AP)as an initial symptom is extremely rare.Only once in the literature,the leukemia cells in AML have been implicated as the cause of AP.Pancreatitis caused by a rare predisposing factor is often misdiagnosed as idiopathic pancreatitis or pancreatitis of other common causes.Severe AP(SAP)progresses rapidly with a high fatality rate.Therefore,it is important to identify the predisposing factors in the early stage of SAP,evaluate the condition,determine prognosis,formulate treatment plans,and prevent a recurrence.Here,we describe a case of SAP due to AML.CASE SUMMARY A 61-year-old man presented to the hospital with fever and persistent abdominal pain.Blood analysis presented significantly elevated serum amylase and severe thrombocytopenia.Computed tomography examination of the abdomen revealed peripancreatic inflammatory effusion.The patient had no common etiologies and risk factors for AP,but the concurrent severe thrombocytopenia could not be explained by pancreatitis.Finally,the bone marrow aspirate and biopsy inspection revealed the underlying reason for pancreatitis,AML(M2 type based on the French-American-British classifications system).CONCLUSION Direct infiltration of the pancrease by acute leukemia,particularly AML cells,is an infrequent cause of AP.Therefore,although AP is a rare extramedullary infilt-ration characteristic for AML patients,it should be considered when determining the etiology of AP.

关 键 词：Acute pancreatitis Acute myeloid leukemia Abdominal pain Extramedullary infiltration ETIOLOGY Case report 

分 类 号：R733.71[医药卫生—肿瘤]