Gaseous metabolites as therapeutic targets in ulcerative colitis  

作　　者：Chu K Yao Chen Sarbagili-Shabat 

机构地区：[1]Department of Gastroenterology,Monash University,Melbourne 3004,Australia [2]Pediatric Gastroenterology Unit,PIBD Research Center,Wolfson Medical Center,Holon 5822012,Israel

出　　处：《World Journal of Gastroenterology》2023年第4期682-691,共10页世界胃肠病学杂志（英文版）

摘　　要：Diet therapies are currently under-utilised in optimising clinical outcomes for patients with active ulcerative colitis(UC).Furthermore,existing dietary therapies are framed by poorly defined mechanistic targets to warrant its success.There is good evidence to suggest that microbial production of gaseous metabolites,hydrogen sulfide(H2S)and nitric oxide(NO)are implicated in the development of mucosal inflammation in UC.On a cellular level,exposure of the colonic epithelium to excessive concentrations of these gases are shown to promote functional defects described in UC.Hence,targeting bacterial production of these gases could provide an opportunity to formulate new dietary therapies in UC.Despite the paucity of evidence,there is epidemiological and clinical data to support the concept of reducing mucosal inflammation in UC via dietary strategies that reduce H2S.Several dietary components,namely sulphurcontaining amino acids and inorganic sulphur have been shown to be influential in enhancing colonic H2S production.More recent data suggests increasing the supply of readily fermentable fibre as an effective strategy for H2S reduction.Conversely,very little is known regarding how diet alters microbial production of NO.Hence,the current evidence suggest that a whole diet approach is needed.Finally,biomarkers for assessing changes in microbial gaseous metabolites in response to dietary interventions are very much required.In conclusion,this review identifies a great need for high quality randomised-controlled trials to demonstrate the efficacy of a sulphide-reducing dietary therapy for patients with active UC.

关 键 词：DIET Ulcerative colitis Hydrogen sulfide Nitric oxide Sulphide-reducing diet 

分 类 号：R574.62[医药卫生—消化系统]