Advantageous tactics with certain probiotics for the treatment of graft-versus-host-disease after hematopoietic stem cell transplantation  

作　　者：Sayuri Yoshikawa Kurumi Taniguchi Haruka Sawamura Yuka Ikeda Ai Tsuji Satoru Matsuda 

机构地区：[1]Food Science and Nutrition,Nara Women's University,Nara 630-8506,Japan

出　　处：《World Journal of Hematology》2023年第2期15-24,共10页世界血液学杂志

摘　　要：Hematopoietic stem cell transplantation(HSCT)becomes a standard form of cellular therapy for patients with malignant diseases.HSCT is the first-choice of immunotherapy,although HSCT can be associated with many complications such as graft-versus-host disease(GVHD)which is a major cause of morbidity and mortality after allogeneic HSCT.It has been shown that certain gut microbiota could exert protective and/or regenerative immunomodulatory effects by the production of short-chain fatty acids(SCFAs)such as butyrate in the experimental models of GVHD after allogeneic HSCT.Loss of gut commensal bacteria which can produce SCFAs may worsen dysbiosis,increasing the risk of GVHD.Expression of G-protein coupled receptors such as GPR41 seems to be upre-gulated in the presence of commensal bacteria,which might be associated with the biology of regulatory T cells(Tregs).Treg cells are a suppressive subset of CD4 positive T lymphocytes implicated in the prevention of GVHD after allogeneic HSCT.Here,we discuss the current findings of the relationship between the modification of gut microbiota and the GVHD-related immunity,which suggested that tactics with certain probiotics for the beneficial symbiosis in gut-immune axis might lead to the elevation of safety in the allogeneic HSCT.

关 键 词：Gut microbiota Hematopoietic stem cell Reactive oxygen species Allogeneic hematopoietic stem cell transplantation Graft vs host disease Gut-immune axis©The Author(s)2023.Published by Baishideng Publishing Group Inc.All rights reserved. 

分 类 号：R73[医药卫生—肿瘤]