Preparation of functional coating on magnesium alloy with hydrophilic polymers and bioactive peptides for improved corrosion resistance and biocompatibility  

作　　者：Lingchuang Bai Yahui Wang Lan Chen Jun Wang Jingan Li Shijie Zhu Liguo Wang Shaokang Guan 

机构地区：[1]School of Materials Science and Engineering,Zhengzhou University,Zhengzhou 450001,China [2]Henan Key Laboratory of Advanced Magnesium Alloys,Zhengzhou 450002,China [3]Key Laboratory of Materials Processing and Mold Technology(Ministry of Education),Zhengzhou 450002,China

出　　处：《Journal of Magnesium and Alloys》2022年第7期1957-1971,共15页镁合金学报（英文）

基　　金：project was the National Natural Science Foundation of China(Grant No.52101291);China Postdoctoral Science Foundation(Grant No.2020TQ0273);the National Key Research and Development Program of China(Grant No.2018YFC1106703);the Key Projects of the Joint Fund of the National Natural Science Foundation of China(Grant No.U1804251)。

摘　　要：Biodegradable magnesium alloy stents(MAS)have great potential in the treatment of cardiovascular diseases.However,too fast degradation and the poor biocompatibility are still two key problems for the clinical utility of MAS.In the present work,a functional coating composed of hydrophilic polymers and bioactive peptides was constructed on magnesium alloy to improve its corrosion resistance and biocompatibility in vitro and in vivo.Mg-Zn-Y-Nd(ZE21B)alloy modified with the functional coating exhibited moderate surface hydrophilicity and enhanced corrosion resistance.The favourable hemocompatibility of ZE21B alloy with the functional coating was confirmed by the in vitro blood experiments.Moreover,the modified ZE21B alloy could selectively promote the adhesion,proliferation,and migration of endothelial cells(ECs),but suppress these behaviors of smooth muscle cells(SMCs).Furthermore,the modified ZE21B alloy wires could alleviate intimal hyperplasia,enhance corrosion resistance and re-endothelialization in vivo transplantation experiment.These results collectively demonstrated that the functional coating improved the corrosion resistance and biocompatibility of ZE21B alloy.This functional coating provides new insight into the design and development of novel biodegradable stents for biomedical engineering.

关 键 词：Magnesium alloy stent Functional coating Corrosion resistance BIOCOMPATIBILITY Hemocompatibility ENDOTHELIALIZATION 

分 类 号：TG174.4[金属学及工艺—金属表面处理]