Role of natural products and intestinal flora on type 2 diabetes mellitus treatment  

作　　者：Ozlem Celik Aydin Sonay Aydın Sureyya Barun 

机构地区：[1]Department of Medical Pharmacology,Erzincan Mengücek Gazi Training and Research Hospital,Erzincan 24100,Turkey [2]Department of Radiology,Erzincan Binali Yıldırım University,Mengücek Gazi Training and Research Hospital,Erzincan 24100,Turkey [3]Department of Medical Pharmacology,Gazi University Faculty of Medicine,Ankara 06500,Turkey

出　　处：《World Journal of Clinical Cases》2023年第1期65-72,共8页世界临床病例杂志

摘　　要：Diabetes mellitus(DM)is a complicated,globally expanding disease that is influenced by hereditary and environmental variables.Changes in modern society’s food choices,physical inactivity,and obesity are significant factors in the development of type 2 DM(T2DM).The association between changes in intestinal flora and numerous disorders,including obesity,diabetes,and cardiovascular diseases,has been studied in recent years.The purpose of this review is to analyze the mechanisms underlying the alteration of the diabetic patients’intestinal flora,as well as their therapeutic choices.Also included is a summary of the antidiabetic benefits of natural compounds demonstrated by studies.The short-chain fatty acids theory,the bile acid theory,and the endotoxin theory are all potential methods by which intestinal flora contributes to the establishment and progression of T2DM.Due to an intestinal flora imbalance,abnormalities in shortchain fatty acids and secondary bile acids have been found in diabetic patients.Additionally,metabolic endotoxemia with altering flora induces a systemic inflammatory response by stimulating the immune system via bacterial translocation.The agenda for diabetes treatment includes the use of short-chain fatty acids,probiotics,prebiotics in the diet,fecal bacteria transplantation,and antibiotics.Animal studies have proven the antidiabetic benefits of numerous bioactive substances,including Flavonoids,Alkaloids,Saponin,and Allicin.However,further research is required to contribute to the treatment of diabetes.

关 键 词：Diabetes mellitus Intestinal flora Natural products ENDOTOXEMIA Bioactive compounds PROBIOTICS 

分 类 号：R587.1[医药卫生—内分泌]