ENDOTOXEMIA

作品数：74被引量：477H指数：12
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相关领域：医药卫生更多>>
相关作者：陈惠孙卢儒权肖南胡德耀梅建民更多>>
相关机构：第三军医大学大坪医院首都医科大学中南大学新乡医学院第一附属医院更多>>
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相关基金：国家自然科学基金中国科学院科研项目上海市教育委员会重点学科基金中国博士后科学基金更多>>
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Protective Effect of Silibinin on Lipopolysaccharide-Induced Endotoxemia by Inhibiting Caspase-11-Dependent Cell Pyroptosis
《Chinese Journal of Integrative Medicine》2024年第10期917-926,共10页OU Jin-ying LIU Shan-hong TANG Dong-kai SHI Ling-zhu YAN Li-jun HUANG Jing-yan ZOU Li-fang QUAN Jing-yu YOU Yan-ting CHEN Yu-yao YU Lin-zhong LU Zi-bin 
Supported by the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515011106);Science and Technology Program of Guangzhou(No.2023A04J1826)。
Objective:To explore the protective effect and the underlying mechanism of silibinin(SIB),one of the active compounds from Silybum marianum(L.)Gaertn in endotoxemia.Methods:Mouse peritoneal macrophage were isolated vi...
关键词：SILIBININ caspase-11 ENDOTOXEMIA PYROPTOSIS inflammation 
Gut microbiota dysbiosis contributes toα-synuclein-related pathology associated with C/EBPβ/AEP signaling activation in a mouse model of Parkinson’s disease被引量：4
《Neural Regeneration Research》2024年第9期2081-2088,共8页Xiaoli Fang Sha Liu Bilal Muhammad Mingxuan Zheng Xing Ge Yan Xu Shu Kan Yang Zhang Yinghua Yu Kuiyang Zheng Deqin Geng Chun-Feng Liu 
supported by Jiangsu Provincial Medical Key Discipline,No.ZDXK202217(to CFL);Jiangsu Planned Projects for Postdoctoral Research Funds,No.1601056C(to SL).
Parkinson’s disease is a neurodegenerative disease characterized by motor and gastrointestinal dysfunction.Gastrointestinal dysfunction can precede the onset of motor symptoms by several years.Gut microbiota dysbiosi...
关键词：C/EBP/AEP signaling pathway ENDOTOXEMIA fecal microbiota transplantation intestinal barrier intestinal inflammation microbiota-gut-brain axis Parkinson’s disease 
Junshanyinzhen tea extract prevents obesity by regulating gut microbiota and metabolic endotoxemia in high-fat diet fed rats
《Food Science and Human Wellness》2024年第4期2036-2047,共12页Jian Ouyang Xiuping Li Changwei Liu Danmin Lu Jie Ouyang Fang Zhou Qi Liu Jianan Huang Zhonghua Liu 
supported by National Modern Agricultural Industry Technology System(CARS-23);Yueyang Yellow Tea Product Innovation Research Project(2018xny-js053).
Obesity is associated with gut dysbiosis and metabolic endotoxin.Junshanyinzhen tea extract(JSTE)reduced fat accumulation and body weight in obese mice.However,the effects and mechanism of JSTE in preventing obesity w...
关键词：Junshanyinzhen tea OBESITY Gut microbiota Gut barrier function Metabolic endotoxemia 
Gut Microbiota and Cytokine Profile in Cirrhosis
《Journal of Clinical and Translational Hepatology》2024年第8期689-700,共12页Irina Efremova Roman Maslennikov Anna Kudryavtseva Anastasia Avdeeva George Krasnov Mikhail Diatroptov Vyacheslav Bakhitov Salekh Aliev Natalia Sedova Maria Fedorova Elena Poluektova Oxana Zolnikova Nariman Aliev Anna Levshina Vladimir Ivashkin 
supported by the Biocodex Microbiota Foundation(National Research Grant Russia 2019).The sponsor did not participate in the development of the study design,influence the conduct of the study,data analysis,or the decision to publish.
Background and Aims:Gut dysbiosis and abnormal cytokine profiles are common in cirrhosis.This study aimed to evaluate the correlations between them.Methods:In the blood plasma of cirrhosis patients and controls,27 cyt...
关键词：ENDOTOXIN Leaky gut Gut microbiome Systemic inflammation Gut-liver axis ENDOTOXEMIA 
Intestinal epithelial Krüppel-like factor 4 alleviates endotoxemia and atherosclerosis through improving NF-κB/miR-34a-mediated intestinal permeability
《Acta Pharmacologica Sinica》2024年第6期1189-1200,共12页He-zhong-rong Nie Yi-wen Zhou Xiao-hong Yu Cong-guo Yin Ling-fei Li Hui-qin Hao Tao Yuan Yong Pan 
financially supported by Guangdong Basic and Applied Basic Research Foundation(2023A1515030096);Basic Research Fund of Shenzhen Science and Technology Innovation Commission(JCYJ20220530154002006 and JCYJ20220530154003007);National Natural Science Foundation of China(81902113);Medical Scientific Research Foundation of Guangdong Province(A2022308);Scientific Research Foundation for Young Teacher of Shenzhen University(000002111207).
Maintenance of intestinal barrier function contributes to gastrointestinal homeostasis and therefore cardiovascular diseases.A number of studies show that intestinal permeability is affected by excessive inflammatory ...
关键词：ATHEROSCLEROSIS Kruppel-like factor 4 intestinal permeability INFLAMMATION 
Sustained induction of IP-10 by MRP8/14 via the IFNβ-IRF7 axis in macrophages exaggerates lung injury in endotoxemic mice被引量：2
《Burns & Trauma》2023年第1期273-288,共16页Juan Wang Guiming Chen Lei Li Sidan Luo Bingrong Hu Jia Xu Haihua Luo Shan Li Yong Jiang 
supported by grants from the National Natural Science Foundation of China(82130063,81971895 and 81501691);Special Support Plan for Outstanding Talents of Guangdong Province(2019JC05Y340).
Background:As a damage-associated molecular pattern,the myeloid-related protein 8/14(MRP8/14)heterodimer mediates various inflammatory diseases,such as sepsis.However,how MRP8/14 promotes lung injury by regulating the...
关键词：ENDOTOXEMIA Interferon-inducible protein 10 Interferon beta Macrophage Myeloid-related protein 8/14 Interferon regulatory factor-7 
Role of natural products and intestinal flora on type 2 diabetes mellitus treatment被引量：2
《World Journal of Clinical Cases》2023年第1期65-72,共8页Ozlem Celik Aydin Sonay Aydın Sureyya Barun 
Diabetes mellitus(DM)is a complicated,globally expanding disease that is influenced by hereditary and environmental variables.Changes in modern society’s food choices,physical inactivity,and obesity are significant f...
关键词：Diabetes mellitus Intestinal flora Natural products ENDOTOXEMIA Bioactive compounds PROBIOTICS 
Simvastatin Improves Outcomes of Endotoxin-induced Coagulopathy by Regulating Intestinal Microenvironment被引量：1
《Current Medical Science》2022年第1期26-38,共13页Min XU Li-li LUO Meng-yi DU Lu TANG Jie ZHOU Yu HU Heng MEI 
This study was supported by grants from the National Natural Science Foundation of China(No.81873434)and the Natural Science Foundation of Hubei Province(No.2020CFA065).
Objective:The systemic inflammatory response is regarded as the major cause of endotoxin-induced coagulopathy,which is a strong predictor of mortality in patients with severe sepsis.Simvastatin plays an important role...
关键词：ENDOTOXEMIA endotoxin-induced coagulopathy SIMVASTATIN inflammatory cytokines intestinal permeability intestinal microorganism 
Gut Microbiota Dysbiosis Strengthens Kupffer Cell-mediated Hepatitis B Virus Persistence through Inducing Endotoxemia in Mice被引量：6
《Journal of Clinical and Translational Hepatology》2022年第1期17-25,共9页Wenqing Zhou Jinzhuo Luo Xiaohong Xie Shangqing Yang Dan Zhu Hongming Huang Dongliang Yang Jia Liu 
This work was supported by grants from the National Sci-ence and Technology Major Project for Infectious Diseases of China(Nos.2017ZX10202203-007-006,2017ZX10202202-001-009,2017ZX10202202-002-008,2017ZX10202201-002-003);the National Natural Science Foundation of China(Nos.81461130019,91642118,91742114,8181101231);the Integrated Innovative Team Project for Major Human Dis-eases Program of Tongji Medical College,Huazhong Universi-ty of Science and Technology(HUST),the Double First-Class Disciplines Program of HUST(International Joint Laboratory for Infection and Immunity),the International Cooperation Base of Hubei Province for Infection and Immunity,and Deutsche Forschungsgemeinschaft(Transregio TRR60).
Background and Aims:Change of gut microbiota com-position is associated with the outcome of hepatitis B virus(HBV)infection,yet the related mechanisms are not fully characterized.The objective of this study was to inv...
关键词：Chronic hepatitis B Gut microbiota Kupffer cells T cell IL-10 
Time of dissociation between microcirculation,macrocirculation,and lactate levels in a rabbit model of early endotoxemic shock被引量：3
《Chinese Medical Journal》2020年第18期2153-2160,共8页Hong Zhang Lei Li Jun Wu Hong-Ping Qu Yao-Qing Tang De-Chang Chen 
Background:The relationship between macrocirculation and microcirculation remains controversial.The loss of coherence between microcirculation and macrocirculation has already been found in late-stage sepsis shock.The...
关键词：Shock ENDOTOXEMIA MICROCIRCULATION LACTATE 
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