Simvastatin Improves Outcomes of Endotoxin-induced Coagulopathy by Regulating Intestinal Microenvironment  

作　　者：Min XU Li-li LUO Meng-yi DU Lu TANG Jie ZHOU Yu HU Heng MEI 

机构地区：[1]Institute of Hematology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China [2]Hubei Clinical and Research Center of Thrombosis and Hemostasis,Wuhan 430022,China [3]Collaborative Innovation Center of Hematology,Huazhong University of Science and Technology,Wuhan 430022,China

出　　处：《Current Medical Science》2022年第1期26-38,共13页当代医学科学（英文）

基　　金：This study was supported by grants from the National Natural Science Foundation of China(No.81873434)and the Natural Science Foundation of Hubei Province(No.2020CFA065).

摘　　要：Objective:The systemic inflammatory response is regarded as the major cause of endotoxin-induced coagulopathy,which is a strong predictor of mortality in patients with severe sepsis.Simvastatin plays an important role in reducing inflammation.In addition,the gut has long been hypothesized to be the“motor”of critical illness,driving or aggravating sepsis by the increased intestinal permeability and bacterial translocation.

关 键 词：ENDOTOXEMIA endotoxin-induced coagulopathy SIMVASTATIN inflammatory cytokines intestinal permeability intestinal microorganism 

分 类 号：R57[医药卫生—消化系统]