SILIBININ

作品数：23被引量：113H指数：7
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相关领域：医药卫生更多>>
相关作者：王超慧张晓林张祥建王志宏董立鹏更多>>
相关机构：中山医学大学河北医科大学第二医院安徽医科大学延边大学更多>>
相关期刊：《Hepatobiliary & Pancreatic Diseases International》《Journal of Biomedical Research》《Journal of Cancer Metastasis and Treatment》《Chinese Journal of Integrative Medicine》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Protective Effect of Silibinin on Lipopolysaccharide-Induced Endotoxemia by Inhibiting Caspase-11-Dependent Cell Pyroptosis
《Chinese Journal of Integrative Medicine》2024年第10期917-926,共10页OU Jin-ying LIU Shan-hong TANG Dong-kai SHI Ling-zhu YAN Li-jun HUANG Jing-yan ZOU Li-fang QUAN Jing-yu YOU Yan-ting CHEN Yu-yao YU Lin-zhong LU Zi-bin 
Supported by the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515011106);Science and Technology Program of Guangzhou(No.2023A04J1826)。
Objective:To explore the protective effect and the underlying mechanism of silibinin(SIB),one of the active compounds from Silybum marianum(L.)Gaertn in endotoxemia.Methods:Mouse peritoneal macrophage were isolated vi...
关键词：SILIBININ caspase-11 ENDOTOXEMIA PYROPTOSIS inflammation 
Silibinin relieves UVB-induced apoptosis of human skin cells by inhibiting the YAP-p73 pathway被引量：1
《Acta Pharmacologica Sinica》2022年第8期2156-2167,共12页Wei-wei Liu Fang Wang Can Li Xiao-yu Song Wuxiyar Otkur Yu-ying Zhu Toshihiko Hayashi Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima 
supported by the National Natural Science Foundation of China(No.81703528).
Excessive exposure to UVB induces skin diseases.Silibinin,a flavonolignan used for treating liver diseases,is found to be effective against UVB-caused skin epidermal and dermal cell damage.In this study we investigate...
关键词：UVB apoptosis HaCaT cells HFF primary fibroblasts YAP TEAD P73 SILIBININ VERTEPORFIN 
Targeted delivery of hyaluronic acid nanomicelles to hepatic stellate cells in hepatic fibrosis rats被引量：12
《Acta Pharmaceutica Sinica B》2020年第4期693-710,共18页Wenhao Li Chuchu Zhou Yao Fu Tijia Chen Xing Liu Zhirong Zhang Tao Gong 
financially supported by National Natural Science Foundation of China(81673359);Sichuan Major Science and Technology Project on Biotechnology and Medicine(No.2018SZDZX0018,China).
Hepatic fibrosis is one kind of liver diseases with a high mortality rate and incidence.The activation and proliferation of hepatic stellate cells(HSCs)is the most fundamental reason of hepatic fibrosis.There are no s...
关键词：Nanomicelles Hyaluronic ACID HEPATIC stellate CELLS HEPATIC FIBROSIS SILIBININ 
Phytochemicals and cancer chemoprevention被引量：1
《Journal of Cancer Metastasis and Treatment》2020年第1期575-610,共36页Asim Dave Falguni Parande Eun-Jung Park John M.Pezzuto 
This work was supported in part by the California Table Grape Commission.
The unending morbidity and mortality that results from cancer,as well as adverse reactions due to chemotherapy and the enormous economic burden of treatment and hospitalization,advocates for the necessity of chemoprev...
关键词：CHEMOPREVENTION PHYTOCHEMICALS resveratrol curcumin anthocyanins SILIBININ LYCOPENE epigallocatechin-3-gallate anti-cancer activity 
Combinatorial treatment of curcumin or silibinin with doxorubicin sensitises high-risk neuroblastoma
《Journal of Cancer Metastasis and Treatment》2020年第1期63-73,共11页Pamali Fonseka Lahiru Gangoda Mohashin Pathan Di Giannatale Angela Suresh Mathivanan 
Suresh Mathivanan is supported by Australian Research Council Future Fellowship(FT180100333);the project was not funded by the basic science fellowship.Angela Di Giannatale is supported by a Grant from the Italian Ministry of Health(GR-2016-02364088).
Aim:Neuroblastoma is a pediatric cancer of the sympathetic nervous system.Using various parameters including stage of the disease,amplification status of N-Myc,DNA index and histopathology,neuroblastoma can be stratif...
关键词：NEUROBLASTOMA epithelial-to-mesenchymal transition CURCUMIN SILIBININ combinatorial therapy 
Author Correction: Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer被引量：1
《Acta Pharmacologica Sinica》2019年第9期1258-1258,共1页Xin-yue Dong Tian-qun Lang Qi Yin Peng-cheng Zhang Ya-ping Li 
The authors apologize that due to our neglect, in the initially published version of this article, wrong images were pasted for the C6 group when doing the pictures layout of Fig. 3. Because the related text in the pa...
关键词：FLUORESCENCE intensity FLUORESCENCE apologize 
Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway被引量：16
《Acta Pharmaceutica Sinica B》2019年第4期745-757,共13页Yayun Liu Wei Xu Ting Zhai Jiaojiao You Yong Chen 
supported by Major Technological Innovation Project of Hubei Province(Grant no.2016ACA140,China);Innovation and Entrepreneurship Training Project for College Students of the Ministry of Education(Grant no.201610512001,China)
Non-alcoholic steatohepatitis(NASH) is a chronic metabolic syndrome and the CFLAR-JNK pathway can reverse the process of NASH. Although silibinin is used for the treatment of NASH in clinical, its effect on CFLAR-JNK ...
关键词：SILIBININ NASH CFLAR LIPID ACCUMULATION Oxidation stress 
Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer被引量：4
《Acta Pharmacologica Sinica》2017年第12期1655-1662,共8页Xin-yue DONG Tian-qun LANG Qi YIN Peng-cheng ZHANG Ya-ping LI 
The National Basic Research Program of China （2014CB931900）, the National Natural Science Foundation of China （81521005 81230029）, and the Youth Innovation Promotion Association of CAS （2015226） are gratefully acknowledged for financial support.
Breast cancer is the most vicious killer for women, and tumor metastasis is one of the leading causes of breast cancer therapy failure In this study, a new pH-sensitive polymer （polyethylene glycol-block-poly[（1,4-b...
关键词：pH-sensitive polymer CO-DELIVERY MICELLE DOCETAXEL SILIBININ breast cancer mouse breast cancer cell line 4T1 metastasis 
Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression被引量：8
《Hepatobiliary & Pancreatic Diseases International》2017年第1期80-87,共8页Devaraj Ezhilarasan Jonathan Evraerts Brice Sid Pedro Buc Calderon Sivanesan Karthikeyan Etienne Sokal Mustapha Najimi 
BACKGROUND： Proliferation of hepatic stellate cells （HSCs） plays a pivotal role in the progression of liver fibrosis conse- quent to chronic liver injury. Silibinin, a flavonoid compound, has been shown to possess ...
关键词：SILIBININ hepatic stellate cells in vitro cell cycle arrest proliferation 
Crosstalk of ROS/RNS and autophagy in silibinin- induced apoptosis of MCF-7 human breast cancer cells in vitro被引量：12
《Acta Pharmacologica Sinica》2017年第2期277-289,共13页Nan ZHENG Lu LIU Wei-wei LIU Fei LI Toshihiko HAYASHI Shin-ichi TASHIRO Satoshi ONODERA Takashi IKEJIMA 
This research was supported by National Natural Science Foundation of China （No 81273517）.
Reactive oxygen species （ROS） and reactive nitrogen species （RNS） play important roles in regulating cell survival and death. Silibinin is a natural polyphenolic flavonoid isolated from milk thistle with anti-tumo...
关键词：human breast cancer MCF-7 cells MDA-MB-231 cells SILIBININ ERΑ reactive oxygen species （ROS） reactive nitrogenspecies （RNS） AUTOPHAGY apoptosis 
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