supported by the German Research Council(Deutsche Forschungsgemeinschaft,HA3309/3-1/2,HA3309/6-1,HA3309/7-1)。
Skeletal muscles are essential for locomotion,posture,and metabolic regulation.To understand physiological processes,exercise adaptation,and muscle-related disorders,it is critical to understand the molecular pathways...
supported by the National Key R&D Program of China(2022YFA1104900 to Huichang Bi,2022YFA1106700 to Xiao Yang);the National Natural Science Foundation of China(grants 82025034 and U23A20535 to Huichang Bi,grants 82304603 to Shicheng Fan);the Shenzhen Science and Technology Program(No.KQTD20190929174023858 to Huichang Bi,China);the Science and Technology Innovation Project of Guangdong Medical Products Administration(2023ZDZ06 to Huichang Bi,China);the National Postdoctoral Program for Innovative Talents(BX20230151 to Shicheng Fan,China);the China Postdoctoral Science Foundation(2023M731570 to Shicheng Fan);the Guangdong Basic and Applied Basic Research Foundation(2023A1515012859 to Shicheng Fan,China);the Guangdong Medical Research Foundation(A2023109 to Shicheng Fan,China).
Fenofibrate,a peroxisome proliferator-activated receptor α(PPARα)agonist,is widely prescribed for hyperlipidemia management.Recent studies also showed that it has therapeutic potential in various liver diseases.Howe...
supported by the grants from the National Key Research and Development Program of China(No.2019YFA0802001 to L.Z.);the National Natural Science Foundation of China(Nos.32030025,32293233 and 32221002 to L.Z.,and No.32270763 to N.Z.);the Shanghai Municipal Science and Technology Major Project,and the Shanghai Leading Talents Program to L.Z.
Evolutionarily conserved,the Hippo signaling pathway is critical in regulating organ size and tissue homeostasis.The activity of this pathway is tightly regulated under normal circumstances,since its physical function...
supported by the National Natural Science Foundation of China(No.81703528).
Excessive exposure to UVB induces skin diseases.Silibinin,a flavonolignan used for treating liver diseases,is found to be effective against UVB-caused skin epidermal and dermal cell damage.In this study we investigate...
Hippo Tumor Suppressor Pathway is the main pathway for cell growth that regulates tissue enlargement and organ size by limiting cell growth.This pathway is activated in response to cell cycle arrest signals(cell polar...