HEPATOMEGALY

作品数：26被引量：44H指数：4
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Epidemiological, Clinical and Etiological Aspects of Adult Hepatomegaly at the Gabriel Touré University Hospital of Bamako in 2023
《Open Journal of Gastroenterology》2024年第11期369-378,共10页Kadiatou Doumbia Hourouma Sow Moussa Younoussou Dicko Mariam Guitteye Sanra Déborah Sanogo Makan Siré Tounkara Kalba Péliaba Amadou Traoré Ouatou Mallé Abdoulaye Maïga Ganda Soumaré Mamadou Sissoko Anselme Konaté Moussa Tiémoko Diarra Moussa Youssoufa Maïga 
Summary: Hepatomegaly is one of the clinical signs commonly encountered in chronic liver disease. The aim of our study was to study the epidemiological, clinical and etiological aspects of hepatomegaly in the hepato-g...
关键词：HEPATOMEGALY Epidemiology CLINICAL ETIOLOGY Gabriel Toure University Hospital BAMAKO 
Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway
《Acta Pharmaceutica Sinica B》2024年第7期2992-3008,共17页Shicheng Fan Yue Gao Pengfei Zhao Guomin Xie Yanying Zhou Xiao Yang Xuan Li Shuaishuai Zhang Frank JGonzalez Aijuan Qu Min Huangb Huichang Bi 
supported by the National Key R&D Program of China(2022YFA1104900 to Huichang Bi,2022YFA1106700 to Xiao Yang);the National Natural Science Foundation of China(grants 82025034 and U23A20535 to Huichang Bi,grants 82304603 to Shicheng Fan);the Shenzhen Science and Technology Program(No.KQTD20190929174023858 to Huichang Bi,China);the Science and Technology Innovation Project of Guangdong Medical Products Administration(2023ZDZ06 to Huichang Bi,China);the National Postdoctoral Program for Innovative Talents(BX20230151 to Shicheng Fan,China);the China Postdoctoral Science Foundation(2023M731570 to Shicheng Fan);the Guangdong Basic and Applied Basic Research Foundation(2023A1515012859 to Shicheng Fan,China);the Guangdong Medical Research Foundation(A2023109 to Shicheng Fan,China).
Fenofibrate,a peroxisome proliferator-activated receptor α(PPARα)agonist,is widely prescribed for hyperlipidemia management.Recent studies also showed that it has therapeutic potential in various liver diseases.Howe...
关键词：FENOFIBRATE PPARa HEPATOMEGALY Partial hepatectomy Liver regeneration YAP TEAD UBIQUITINATION 
Hepatomegaly and jaundice as the presenting symptoms of systemic light-chain amyloidosis: A case report
《World Journal of Gastrointestinal Oncology》2024年第2期550-556,共7页Xu Zhang Fei Tang Yan-Ying Gao De-Zhao Song Jing Liang 
Tianjin Key Medical Discipline(Specialty)Construction Project,No.TJYXZDXK-034A.
BACKGROUND Light chain(AL)amyloidosis is a plasma cell dyscrasia characterized by the pathologic production and extracellular tissue deposition of fibrillar proteins derived from immunoglobulin AL fragments secreted b...
关键词：JAUNDICE HEPATOMEGALY Liver amyloidosis Kappa light chain Pseudo-Budd-Chiari syndrome Case report 
Niemann-Pick A/B Disease in a 13-Year-Old Child and Review of the Literature
《Open Journal of Pediatrics》2023年第6期907-913,共7页Issam Taha Ilham Tadmori Moustapha Hida 
Niemann-Pick disease (NPD) refers to a group of patients who have varying degrees of lipid storage and foam cell infiltration in tissues, as well as overlapping clinical features, including hepatosplenomegaly, insuffi...
关键词：Nieman Pick SPLENOMEGALY HEPATOMEGALY Enzymatic Test 
Peroxisome proliferator-activated receptor α agonist induces mouse hepatomegaly through the spatial hepatocyte enlargement and proliferation被引量：1
《Acta Pharmacologica Sinica》2023年第10期2037-2047,共11页Jie Yang Xiao Yang Yi-fei Zhang Jia-ning Tian Shi-cheng Fan Yue Gao Hui-lin Li Cheng-hui Cai Min Huang Hui-chang Bi 
supported by the National Key R&D Program of China(2022YFA1104900);the National Natural Science Foundation of China(82025034,82000593,81973392,82020108031);the Shenzhen Science and Technology Program(KQTD20190929174023858);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y093);the China Postdoctoral Science Foundation(2019TQ0398,2020M673028).
Peroxisome proliferator-activated receptor alpha(PPARα)activation-induced hepatomegaly is accompanied by hepatocyte hypertrophy around the central vein(CV)area and hepatocyte proliferation around the portal vein(PV)a...
关键词：peroxisome proliferator-activated receptorα HEPATOMEGALY spatial distribution hepatocyte proliferation hepatocyte hypertrophy 
Ypel5 regulates liver development and function in zebrafish
《Journal of Molecular Cell Biology》2023年第3期44-54,共11页Yun Deng Xiao Han Huiqiao Chen Chaoxian Zhao Yi Chen Jun Zhou Hugues de The Jun Zhu Hao Yuan 
supported by the National Natural Science Foundation of China(31371479).
YPEL5 is a member of the Yippee-like(YPEL)gene family that is evolutionarily conserved in eukaryotic species.To date,the physiological function of YPEL5 has not been assessed due to a paucity of genetic animal models....
关键词：YPEL5 HEPATOMEGALY hepatic function HNF4A PPARαsignaling 
Liver involvement in patients with COVID-19 infection:A comprehensive overview of diagnostic imaging features
《World Journal of Gastroenterology》2023年第5期834-850,共17页Davide Ippolito Cesare Maino Federica Vernuccio Roberto Cannella Riccardo Inchingolo Michele Dezio Riccardo Faletti Pietro Andrea Bonaffini Marco Gatti Sandro Sironi 
During the first wave of the pandemic,coronavirus disease 2019(COVID-19)infection has been considered mainly as a pulmonary infection.However,different clinical and radiological manifestations were observed over time,...
关键词：Liver Fatty liver HEPATOMEGALY Hepatic infarction Liver diseases Liver failure Biliary tract diseases COVID-19 SARS-CoV-2 INFECTION X-Ray computed tomography Magnetic resonance imaging ULTRASONOGRAPHY ADULTS PEDIATRICS 
Long-term treatment with the mPXR agonist PCN promotes hepatomegaly and lipid accumulation without hepatocyte proliferation in mice
《Acta Pharmacologica Sinica》2023年第1期169-177,共9页Yi-fei Zhang Yue Gao Jie Yang Yi-ming Jiang Min Huang Shi-cheng Fan Hui-chang Bi 
The work was supported by the National Natural Science Foundation of China [Grant number:82025034,81973392];the National Key Research and Development Program (Grant number:2017YFE0109900);the Shenzhen Science and Technology Program (KQTD20190929174023858);the 111 project (Grant number:B16047);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [Grant number:2017BT01Y093].
Pregnane X receptor(PXR)is highly expressed in the liver and plays a pivotal role in xenobiotic and endobiotic metabolism.We previously reported that PXR activation by its specific mouse agonist pregnenolone 16α-carb...
关键词：pregnane X receptor(PXR) AGONIST PCN HEPATOMEGALY LIPIDOMICS triglyceride accumulation 
Epidemiological, Clinical, Paraclinical, Etiological and Therapeutic Aspects of Liver Cirrhosis in the Hepato-Gastroenterology Department of the Hospital Aristide Le Dantec in Dakar
《Open Journal of Gastroenterology》2022年第11期317-323,共7页Marie Louise Bassène Salamata Diallo Marieme Polele Fall Mame Aissé Thioubou Téné Sidibé Coumba Cissé Mamadou Ngoné Gueye 
Introduction: Liver cirrhosis is a global public health issue. Our aim was to determine the epidemiological, clinical, paraclinical and therapeutic aspects of liver cirrhosis in the hepato-gastroenterology department ...
关键词：Cirrhosis Viral Hepatitis B Portal Hypertension Liver Failure HEPATOMEGALY 
Schisandrae Fructus oil-induced elevation in serum triglyceride and lipoprotein concentrations associated with physiologic hepatomegaly in mice
《Asian Pacific Journal of Tropical Biomedicine》2022年第2期59-68,共10页Si-Yuan Pan Xue-Lan Song Zhao-Heng Lin Qing Yu Yi Zhang Hai-Chuan Tai Gan Luo Xiao-Yan Wang Pei-Li Zhu Nan Sun Zhu-Sheng Chu Zhi-Ling Yu Yi Zhang Kam-Ming Ko 
supported by the National Natural Science Foundation of China(No.81803793 and 31071989);the Young Scientist Program by Beijing University of Chinese Medicine。
Objective:To investigate hypertriglyceridemia and hepatomegaly caused by Schisandrae Sphenantherae Fructus(FSS)and Schisandra chinensis Fructus(FSC)oils in mice.Methods:Mice were orally administered a single dose of S...
关键词：Schisandrae Fructus oils TRIGLYCERIDE Alanine aminotransferase HEPATOMEGALY Mouse model HYPERTRIGLYCERIDEMIA 
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