VERTEPORFIN

作品数：25被引量：13H指数：2
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Extrusion/Inkjet Printing of Verteporfin-Loaded Bilayer Skin Substitutes for Wound Healing and Structure Reconstruction
《Journal of Bionic Engineering》2024年第6期2969-2984,共16页Tian Jiao Ruilu Zhou Junrong Jiao Junna Jiao Qin Lian 
funded by Nanyang Normal University Natural Science Doctor Research Starting Fund Project,2024ZX026,Tian Jiao。
The shortage of transplantable skin is the leading cause of death in patients with extensive skin defect.Addressing this challenge urgently requires the development of skin substitutes capable of wound repair and faci...
关键词：BIOPRINTING Multicellular printing BIOMIMETIC Skin substitutes Wound healing 
Verteporfin fluorescence in antineoplastic-treated pancreatic cancer cells found concentrated in mitochondria
《World Journal of Gastrointestinal Oncology》2024年第3期968-978,共11页Ying-Qiao Zhang Qing-Hao Liu Lu Liu Peng-Yu Guo Run-Ze Wang Zhi-Chang Ba 
BACKGROUND Traditional treatments for pancreatic cancer(PC)are inadequate.Photodynamic therapy(PDT)is non-invasive,and proven safe to kill cancer cells,including PC.However,the mitochondrial concentration of the photo...
关键词：Photodynamic therapy Pancreatic cancer VERTEPORFIN MITOCHONDRIA CHEMOTHERAPY GEMCITABINE 
YAP抑制药Verteporfin增强肝细胞癌导管动脉化疗栓塞术治疗大鼠的疗效被引量：1
《中国临床药理学杂志》2023年第20期2970-2974,共5页高兴强 窦晓静 郭燕春 王其亮 
目的 观察Yes相关蛋白抑制药Verteporfin联合经导管动脉化疗栓塞术(TACE)治疗对N-亚硝基二乙胺(DEN)诱导肝癌大鼠肿瘤生长的抑制作用。方法 用DEN饲喂法构建肝癌大鼠,并将建模成功的大鼠随机分为对照组、TACE组(给予TACE治疗)、Vertepor...
关键词：VERTEPORFIN 肝癌 肿瘤生长 经导管肝动脉化疗栓塞术 血管生成 
YAP抑制剂Verteporfin对食管癌细胞存活和同质黏附能力的影响
《生命的化学》2023年第2期296-302,共7页王秀丽 李婷 杨子怡 李鑫婷 赵蓉 赵欣冉 杨佳程 李晓钟 王晓霞 
山西省自然科学基金项目(202103021224385)
为探讨Yes相关蛋白(Yes-associated protein,YAP)抑制剂Verteporfin(VP)对食管癌细胞存活和同质黏附(即细胞间黏附)能力的影响,采用噻唑蓝(thiazolyl blue tetrazolium bromide,MTT)比色法检测了不同浓度的VP对食管癌细胞KYSE150和KYSE3...
关键词：Yes相关蛋白抑制剂 VERTEPORFIN 同质黏附能力 食管癌 
Verteporfin synergizes the efflcacy of anti-PD-1 in cholangiocarcinoma被引量：3
《Hepatobiliary & Pancreatic Diseases International》2022年第5期485-492,共8页Jianyang Fu Nicole A McGrath Jihye Lee Xin Wang Gagandeep Brar Changqing Xie 
supported by the Physician-Scientist Early Investigator Program at National Cancer Institute,National Institute of Health(ZIA BC 011888)。
Background:Cholangiocarcinoma(CCA)is one of the primary hepatobiliary malignant neoplasms with only 10%of 5-year survival rate.Promising immunotherapy with the blockade of immune checkpoints has no clear benefit in CC...
关键词：VERTEPORFIN YAP1 Anti-programmed cell death-1 IMMUNOTHERAPY CHOLANGIOCARCINOMA 
Silibinin relieves UVB-induced apoptosis of human skin cells by inhibiting the YAP-p73 pathway被引量：1
《Acta Pharmacologica Sinica》2022年第8期2156-2167,共12页Wei-wei Liu Fang Wang Can Li Xiao-yu Song Wuxiyar Otkur Yu-ying Zhu Toshihiko Hayashi Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima 
supported by the National Natural Science Foundation of China(No.81703528).
Excessive exposure to UVB induces skin diseases.Silibinin,a flavonolignan used for treating liver diseases,is found to be effective against UVB-caused skin epidermal and dermal cell damage.In this study we investigate...
关键词：UVB apoptosis HaCaT cells HFF primary fibroblasts YAP TEAD P73 SILIBININ VERTEPORFIN 
Verteporfin-mediated on/off photoswitching functions synergistically to treat choroidal vascular diseases
《Bioactive Materials》2022年第8期402-415,共14页Yahan Ju Xiaochan Dai Zhimin Tang Zunzhen Ming Ni Ni Dongqing Zhu Jing Zhang Bo Ma Jiajing Wang Rui Huang Siyu Zhao Yan Pang Ping Gu 
supported by the National Natural Science Foundation of China(81870687,82071004,32000972);the National Key R&D program of China(2018YFC1106100);the Key program of Shanghai Science and Technology Commission(19JC1415503);the Municipal Education Commission-Gaofeng Clinical Medicine Grant Support(20161316,20191820);Cross-disciplinary Research Fund of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(No.JYJC201907);Science and Technology Commission of Shanghai(20DZ2270800).
Choroidal vascular diseases,such as age-related macular degeneration,are the leading cause of vision impairment and are characterized by pathological angiogenesis.Verteporfin-mediated photodynamic therapy is a current...
关键词：Pathological neovascularization Photodynamic therapy Bio-responsive release In situ drug delivery 
ProtoporphyrinⅨand verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2
《Science Bulletin》2021年第9期925-936,M0004,共13页Chenjian Gu Yang Wu Huimin Guo Yuanfei Zhu Wei Xu Yuyan Wang Yu Zhou Zhiping Sun Xia Cai Yutang Li Jing Liu Zhong Huang Zhenghong Yuan Rong Zhang Qiang Deng Di Qu Youhua Xie 
supported by the National Science and Technology Major Project(NSTMP)for the Prevention and Treatment of Infectious Diseases(2018ZX10734401,2018ZX10301208);the NSTMP for the Development of Novel Drugs(2019ZX09721001);the Project of Novel Coronavirus Research of Fudan University,China Postdoctoral Science Foundation(2020T130016ZX)。
The SARS-CoV-2 infection is spreading rapidly worldwide.Efficacious antiviral therapeutics against SARSCo V-2 is urgently needed.Here,we discovered that protoporphyrin IX(Pp IX)and verteporfin,two Food and Drug Admini...
关键词：SARS-CoV-2 ACE2 ProtoporphyrinⅨ VERTEPORFIN 
YAP对梅花鹿鹿茸间充质细胞增殖与分化的影响被引量：2
《中国兽医学报》2021年第2期315-321,共7页张静 柳舒 黄吉成 岳占碰 杨占清 郭斌 
吉林省自然科学基金资助项目(20180101247JC);国家自然科学基金资助项目(31873003)。
以梅花鹿为研究对象,通过流式细胞术、荧光定量PCR等方法,探讨YAP(Yes-associated protein,即Yes相关蛋白)对鹿茸间充质细胞增殖与分化的影响。分离培养鹿茸间充质细胞,添加一定浓度的YAP抑制剂Verteporfin后,通过流式细胞术检测发现,...
关键词：YAP VERTEPORFIN 鹿茸 间充质细胞 增殖 分化 
Efficacy of 1/3-Dose Verteporfin Photodynamic Therapy for Subacute Central Serous Chorioretinopathy
《Open Journal of Ophthalmology》2017年第4期310-318,共9页Li Xu Qiushi Liu Xiaotong Zhuang Dongning Liu 
Purpose: To study the safety and efficacy of 1/3-dose verteporfin photodynamic therapy (PDT) for subacute central serous chorioretinopathy (CSC). Methods: In this case series, 59 eyes (59 patients) diagnosed with suba...
关键词：SUBACUTE CENTRAL Serous CHORIORETINOPATHY (CSC) 1/3-Dose VERTEPORFIN Photodynamic Therapy (PDT) Subfoveal Choroidal Thickness (SCT) Neuroretinal Thickness (NRT) CENTRAL Foveal Thickness (CFT) 
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