The Hippo signaling pathway:from multiple signals to the hallmarks of cancers  

作　　者：Ning Zhu Ruizeng Yang Xiaodong Wang Liang Yuan Xiaoyu Li Fang Wei Lei Zhang 

机构地区：[1]School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China [2]State Key Laboratory of Cell Biology,CAS Center for Excellence in Molecular Cell Science,Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China [3]Sheng Yushou Center of Cell Biology and Immunology,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China [4]School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Hangzhou 310024,China [5]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China

出　　处：《Acta Biochimica et Biophysica Sinica》2023年第6期904-913,共10页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the National Key Research and Development Program of China(No.2019YFA0802001 to L.Z.);the National Natural Science Foundation of China(Nos.32030025,32293233 and 32221002 to L.Z.,and No.32270763 to N.Z.);the Shanghai Municipal Science and Technology Major Project,and the Shanghai Leading Talents Program to L.Z.

摘　　要：Evolutionarily conserved,the Hippo signaling pathway is critical in regulating organ size and tissue homeostasis.The activity of this pathway is tightly regulated under normal circumstances,since its physical function is precisely maintained to control the rate of cell proliferation.Failure of maintenance leads to a variety of tumors.Our un-derstanding of the mechanism of Hippo dysregulation and tumorigenesis is becoming increasingly precise,relying on the emergence of upstream inhibitor or activator and the connection linking Hippo target genes,mutations,and related signaling pathways with phenotypes.In this review,we summarize recent reports on the signaling network of the Hippo pathway in tumorigenesis and progression by exploring its critical mechanisms in cancer biology and potential targeting in cancer therapy.

关 键 词：HIPPO YAP TAZ TEAD signal transduction cancer hallmark 

分 类 号：R730.2[医药卫生—肿瘤]