Metabolic-associated liver disease is a growing public health crisis,with phenotypes from fatty liver to steatohepatitis,previously known as NASH(Non-Alcoholic SteatoHepatitis)and currently rebranded as MASH(Metabolic...
Background:Apoptosis signal-regulating kinase 1(ASK1)is a MAP3K kinase in the MAPK signaling pathway activated by stressors and triggers downstream biological effects such as inflammation and apoptosis;therefore,inhib...
National Natural Science Foundation of China,Grant/Award Number:82174292;Key Project of Jiangsu Provincial Administration of Traditional Chinese Medicine,Grant/Award Number:ZD202312;Natural Science Foundation of Laboratory Medicine School in Chengdu Medical College,Grant/Award Number:JYZK202203;Sichuan Province Science and Technology Program,Grant/Award Number:2024NSFSC0577 and 2021YFG0316;Technology innovation group project of Foshan 2019,Grant/Award Number:FS0AA-KJ919-4402-0027。
Background:The emerging incidence of pathogenic liver conditions is turning into a major concern for global health.Induction of pyroptosis in hepatocytes instigates cel-lular disintegration,which in turn liberates sub...
This work was supported by the grants from the National Key R&D Program of China(Nos.2020YFA0509003 and 2020YFA0509102 to J.C.);the National Natural Science Foundation of China(Nos.31830112,32030024,31900536,32170769 to J.C.,No.32300633 to M.H.,and No.32200642 to S.C.);the Program of Shanghai Academic Research Leader(No.19XD1404200 to J.C.);the China Postdoctoral Science Foundation(No.2023M733487 to M.H.and No.2020M671262 to S.W.);the China Postdoctoral Innovative Talent Support Program(No.BX20190345 to S.W.)。
Nonalcoholic fatty liver disease(NAFLD)is a leading cause of chronic liver disease and poses a substantial health burden with increasing incidence globally.NAFLD encompasses a spectrum extending from hepatic steatosis...