Adult focalβ-cell nesidioblastosis:A case report  

作　　者：Kui Tu Li-Jin Zhao Jin Gu 

机构地区：[1]Department of General Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China

出　　处：《World Journal of Clinical Cases》2023年第1期150-156,共7页世界临床病例杂志

摘　　要：BACKGROUND Nesidioblastosis usually refers to a series of clinical manifestations caused by the proliferation ofβ-cells in pancreatic islets,and these clinical manifestations are hyperinsulinemia and persistent hypoglycemia.According to the size of the lesion,nesidioblastosis is divided into focal nesidioblastosis,diffuse nesidioblastosis and atypical nesidioblastosis,and its pathogenesis is still unclear.Nesidioblastosis is mainly seen in infants and rarely reported in adults,especially focal nesidioblastosis,which is difficult to distinguish from insulinoma.CASE SUMMARY We report a case of adult focalβ-cell nesidioblastosis in which the preoperative diagnosis was insulinoma.The patient was a 48-year-old male who suffered from repeated morning and fasting palpitations,sweating,and severe disturbance of consciousness for 5 years.His blood glucose was found to be as low as 1.79 mmol/L during an attack.However,abdominal computed tomography showed no abnormalities.Magnetic resonance imaging and endoscopic ultrasonography demonstrated a nodular mass in the head of the pancreas,combined with hyperinsulinemia and high serum C-peptide.The patient was diagnosed with insulinoma and underwent Beger surgery;however,the postoperative pathological results showed nesidioblastosis.CONCLUSION Although surgical resection is the preferred option for nesidioblastosis,some cases can be treated non-surgically.In order to increase clinicians’understanding of nesidioblastosis,it is necessary to review the pathogenesis,diagnosis and treatment of this disease.

关 键 词：Focal nesidioblastosis HYPERINSULINEMIA Persistent hypoglycemia Case report 

分 类 号：R587[医药卫生—内分泌]