Solitary hyoid plasmacytoma with unicentric Castleman disease:A case report and review of literature  

作　　者：Yan-Hui Zhang Yi-Feng He Hao Yue Yue-Ni Zhang Lei Shi Bin Jin Pin Dong 

机构地区：[1]Department of Otolaryngology-Head and Neck Surgery,Shanghai General Hospital,Shanghai Jiao Tong University,Shanghai 200080,China [2]Department of Radiology,Shanghai General Hospital,Shanghai Jiao Tong University,Shanghai 200080,China [3]Department of Pathology,Shanghai Cancer Center,Fudan University,Shanghai 200032,China [4]NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150028,Heilongjiang Province,China

出　　处：《World Journal of Clinical Cases》2022年第36期13364-13372,共9页世界临床病例杂志

基　　金：Supported by Key Program of the Medical Engineering Cross Research Fund of Shanghai Jiao Tong University,No.YG2019QNA55;Tou-Yan Innovation Team Program of Heilongjiang Province,No.2019-15。

摘　　要：BACKGROUND Solitary plasmacytoma and unicentric Castleman disease(UCD)are rare lymphoproliferative disorders characterized by monoclonal plasma cells and a single set of locally enlarged lymph nodes,respectively.CASE SUMMARY A 48-year-old Han Chinese man presented to our department with a neck mass and progressive foreign body sensation in his throat.18F-FDG positron emission tomography revealed focally increased radioactivity centered around the hyoid,and computed tomography(CT)revealed osteolytic lesions.Histopathology revealed Castleman-like features and CD138/CD38-positive mature plasma cells.Systemic work-up ruled out the possibility of POEMS syndrome,lymphoma,and multiple myeloma,leading to a final diagnosis of solitary hyoid plasmacytoma with UCD.The patient underwent partial hyoid resection and selective neck dissection,followed by intensity-modulated radiotherapy.99mTc-MDP singlephoton emission computed tomography/CT reevaluation showed neither local recurrence nor distant bone metastasis at the 40-mo follow-up.CONCLUSION The diagnostic process and differential diagnosis of this rare case provided valuable educational information to clinicians.

关 键 词：18F-FDG Positron emission tomography/computed tomography PLASMACYTOMA Hyoid bone Castleman disease Case report 

分 类 号：R733[医药卫生—肿瘤]