基于穆勒矩阵成像全阵元曲线的癌变组织识别  

Cancer Tissue Recognition by Muller Matrix Imaging Full Array Curve

作　　者：高君朝 黄丹飞[1,2] 张乐超 宋东[3] 洪景辉[3] 张丽丽 唐鸿宇[1,2] 周尧 GAO Junzhao;HUANG Dangfei;ZHANG Lechao;SONG Dong;HONG Jinghui;ZHANG Lili;TANG Hongyu;ZHOU Yao(College of Optoelectronic Engineering,Changchun University of Technology,Changchun 130022,China;Zhongshan Research Institute of Changchun University of Technology,Zhongshan 528437,China;The First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]长春理工大学光电工程学院,长春130022 [2]长春理工大学中山研究院,中山528437 [3]吉林大学第一医院,长春130021

出　　处：《光子学报》2023年第2期159-172,共14页Acta Photonica Sinica

基　　金：国家自然科学基金(No.61893096014)。

摘　　要：改进原有背向穆勒矩阵成像装置,采集未染色肺癌、乳腺癌切片,基于穆勒矩阵各阵元的物理含义,借鉴光谱数据生成偏振立方体,纵向提取任意像素全阵元曲线,展示曲线特有的穆勒矩阵信息分析方式。采用夹角余弦曲线分类方法,对照病理标注生成混淆矩阵。其中肺癌、乳腺癌精度可达89.59%、87.82%,高倍率乳腺癌精度为77.52%。全阵元曲线较单一阵元分类准确率更高。本文方法的可视化分析、像素分类、跨尺度特性表明在偏振检测领域有很大的挖掘空间以及应用潜力。As the second most common cause of death in the world,cancer has become a persistent public health challenge facing the world.At present,the most mature treatment for cancer is surgical resection,and the determination of whether the resection is clean depending on the detection of artificial pathological sections.During the operation,it is necessary to repeatedly confirm whether the diseased tissue is removed cleanly,and each test requires the preparation of pathological sections for manual detection.Pathological section staining is tedious and time-consuming,and the process of manual section detection and confirmation is time-consuming and inefficient.Therefore,there is an urgent need for an auxiliary detection method that skips the staining process,and the method is accurate,fast,highly sensitive,non-contact,non-invasive,and highly safe.Polarization is a new information dimension independent of light intensity,wavelength,and phase.Polarization imaging uses the incident light to irradiate the sample to detect the outgoing light and obtain the physical information of the sample.Polarization imaging is a non-invasive,label free,non-contact optical detection technology.The detected polarization information is often represented by Mueller matrix.Mueller matrix characterizes the polarization characteristics of complex media,including rich macro and micro structural information.Mueller matrix imaging can encode rich information on microstructure even under low resolution and wide field conditions.Polarization detection technology has the advantages such as large information,strong compatibility,wide scale,but the microstructure of each element value of Mueller matrix is not directly related to the same product,and it is difficult to characterize due to the mixing of a large number of influencing factors.It is difficult to obtain specific indicators of sample microstructure.Today,the focus on information extraction of Mueller matrix is only on the processing level of individual array elements with obviously different i

关 键 词：偏振成像 穆勒矩阵 癌变组织 特征提取 病理切片检测 

分 类 号：O436.3[机械工程—光学工程]