基因体甲基化与肿瘤的研究进展  

Advances in the study of gene body methylation and tumors

作　　者：王琦[1] 陈勇军[1] Wang Qi;Chen Yongjun(Department of Biliary and Pancreatic Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院胆胰外科,武汉430030

出　　处：《中华肝胆外科杂志》2023年第1期76-80,共5页Chinese Journal of Hepatobiliary Surgery

基　　金：国家自然科学基金(81572783、81974438、82173069)。

摘　　要：DNA甲基化是一种重要的表观遗传学调控机制,包括基因启动子甲基化及基因体甲基化。DNA甲基化异常与恶性肿瘤的发生和进展密切相关,既往对启动子甲基化与肿瘤的相关性已有较为清晰的阐述。然而随着全基因组DNA甲基化的深入研究,发现基因体区域存在更为广泛的甲基化,基因体甲基化在肿瘤相关基因表达、细胞分化、肿瘤发生发展等中也发挥重要作用。本文就近年来基因体甲基化对肿瘤的影响进行综述,深入阐述基因体甲基化对肿瘤的作用及调控机制,为基因体甲基化在肿瘤领域的研究及应用提供线索。DNA methylation is an important epigenetic regulatory mechanism,including gene promoter methylation and gene body methylation.Abnormal DNA methylation is closely related to the development and progression of malignant tumors,and the correlation between promoter methylation and tumors has been more clearly described previously.However,with the in-depth study of genome-wide DNA methylation,it has been found that there are more extensive methylation levels in gene body regions,which also play an important role in tumor-related gene expression,cell differentiation and tumor development.In this paper,we review the effects of gene bodymethylation on tumors in recent years and provide clues for the research and application of gene body methylation in the field of tumors by elaborating the role and regulatory mechanism of gene body methylation on tumors.

关 键 词：DNA甲基化 肿瘤 基因体甲基化 

分 类 号：R730.2[医药卫生—肿瘤]