Abnormal Prefrontal Neural Oscillations are Associated with Social Deficits in MECP2 Duplication Syndrome  

作　　者：Xiao Li Yingnan Nie Qiyu Niu Xuanjun Guo Zilong Qiu Shouyan Wang 

机构地区：[1]Institute of Intelligent Robotics,Academy for Engineering and Technology,Fudan University,Shanghai 200433,China [2]Institute of Science and Technology for Brain-Inspired Intelligence,Fudan University,Shanghai 200433,China [3]Center for Excellence in Brain Science and Intelligence Technology,Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Key Laboratory of Primate Neurobiology,Chinese Academy of Sciences,Shanghai 200031,China [4]National Clinical Research Center for Aging and Medicine,Huashan Hospital,Fudan University,Shanghai 200040,China

出　　处：《Neuroscience Bulletin》2022年第12期1598-1602,共5页神经科学通报（英文版）

基　　金：This work was supported by the National Key R&D Program of China(2018YFC1705800);Shanghai Municipal Science and Technology Major Project(2018SHZDZX01);Shanghai Municipal Science and Technology Major Projects(2021SHZDZX0103 and 2017SHZDZX01)。

摘　　要：DearEditor,Methyl-CpG-binding protein 2(MeCP2)participates in regulating the expression of the CREB,TDP-43 and Dnmtl genes[1,2].Recent studies have shown that MeCP2 is essential for maintaining normal neural functions in the mammalian brain.Overexpression of MeCP2causes MECP2 duplication syndrome[3],a type of autism spectrum disorder that results in a core phenotype of social deficits in human patients[4],nonhuman primates[5],and rodents[6].

关 键 词：MECP2 MECP2 patients 

分 类 号：R338[医药卫生—人体生理学]