非典型抗精神病药诱发代谢综合征和加重认知障碍相关机制的研究进展  

Research progress on the mechanism of atypical antipsychotics inducing metabolic syndrome and aggravating cognitive impairment

作　　者：伊思敏 翁飞鸿 王婷云 魏少卿 李申[1] 时文涛[1] Yin Simin;Weng Feihong;Wang Tingyun;Wei Shaoqing;Li Shen;Shi Wentao(School of Basic Medicine,Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津医科大学基础医学院,300070

出　　处：《神经疾病与精神卫生》2022年第12期894-898,共5页Journal of Neuroscience and Mental Health

基　　金：国家自然科学基金项目(32170649,81801323)。

摘　　要：认知障碍是精神分裂症的核心症状。非典型抗精神病药物治疗容易诱发患者的代谢综合征,而代谢综合征又可进一步加重患者的认知障碍。引起以上临床表现的内在机制主要包括脑源性神经因子机制、胰岛素抵抗机制、肠道菌群机制、免疫炎症机制和微血管病变机制。基于非典型抗精神病药物、代谢综合征和认知障碍之间存在复杂联系,现就3者的关系及已发现的生物学机制予以综述。Cognitive impairment is the core symptom of schizophrenia. Atypical antipsychotics treatment can easily induce metabolic syndrome in patients, and metabolic syndrome can further aggravate their cognitive impairment. The internal mechanisms causing this series of clinical symptoms mainly include the following: brain-derived neurotrophic factor mechanism, insulin resistance mechanism, intestinal flora mechanism, immune inflammation mechanism and micro vasculopathy mechanism. Based on the complicated relationship among atypical antipsychotics, metabolic syndrome and cognitive impairment, this article reviews the correlation among them and the related biological mechanisms that have been discovered.

关 键 词：精神分裂症 非典型抗精神病药物 代谢综合征 认知障碍 综述 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R589[医药卫生—临床医学] R749.1