A Global Multiregional Proteomic Map of the Human Cerebral Cortex  

作　　者：Zhengguang Guo Chen Shao Yang Zhang Wenying Qiu Wenting Li Weimin Zhu Qian Yang Yin Huang Lili Pan Yuepan Dong Haidan Sun Xiaoping Xiao Wei Sun Chao Ma Liwei Zhang 

机构地区：[1]Core Facility of Instrument,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,Beijing 100005,China [2]State Key Laboratory of Proteomics,Beijing Proteome Research Center,National Center for Protein Sciences(Beijing),Beijing Institute of Lifeomics,Beijing 102206,China [3]Department of Neurosurgery,China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China [4]Department of Human Anatomy,Histology,and Embryology,Institute of Basic Medical Sciences,Neuroscience Center,Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,Beijing 100005,China

出　　处：《Genomics, Proteomics & Bioinformatics》2022年第4期614-632,共19页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Neuroscience Center,the China Human Brain Banking Consortium;supported by the National Key R&D Program of China(Grant Nos.2016YFC1306300 and 2018YFC0910202);the National Natural Science Foundation of China(Grant Nos.30970650,31200614,31400669,81371515,81170665,and 81560121);Beijing Medical Research(Grant No.2018-7);Beijing Natural Science Foundation(Grant No.7173264 and 7172076);Beijing cooperative construction project(Grant No.110651103;Beijing Science Program for the Top Young(Grant No.2015000021223TD04);Beijing Normal University(Grant No.11100704);Peking Union Medical College Hospital(Grant No.2016-2.27);CAMS Innovation Fund for Medical Sciences(Grant No.2017-I2M-1-009);the CAMS special basic research fund for central public research institutes(Grant No.2017PT310004);Biologic Medicine Information Center of China;National Scientific Data Sharing Platform for Population and Health。

摘　　要：The Brodmann area(BA)-based map is one of the most widely used cortical maps for studies of human brain functions and in clinical practice;however,the molecular architecture of BAs remains unknown.The present study provided a global multiregional proteomic map of the human cerebral cortex by analyzing 29 BAs.These 29 BAs were grouped into 6 clusters based on similarities in proteomic patterns:the motor and sensory cluster,vision cluster,auditory and Broca’s area cluster,Wernicke’s area cluster,cingulate cortex cluster,and heterogeneous function cluster.We identified 474 cluster-specific and 134 BA-specific signature proteins whose functions are closely associated with specialized functions and disease vulnerability of the corresponding cluster or BA.The findings of the present study could provide explanations for the functional connections between the anterior cingulate cortex and sensorimotor cortex and for anxiety-related function in the sensorimotor cortex.The brain transcriptome and proteome comparison indicates that they both could reflect the function of cerebral cortex,but show different characteristics.These proteomic data are publicly available at the Human Brain Proteome Atlas(www.brain-omics.com).Our results may enhance our understanding of the molecular basis of brain functions and provide an important resource to support human brain research.

关 键 词：Brodmann area PROTEOMICS Cerebral cortex Cingulate cortex Sensorimotor cortex 

分 类 号：Q811.4[生物学—生物工程]