熊果酸的生物活性研究进展  

Research progress on biological activity of ursolic acid

作　　者：田春风 郭宇帆 商佳琪 李凯 包艳[1,2] TIAN Chunfeng;GUO Yufan;SHANG Jiaqi;LI Kai;BAO Yan(School of Public Health,Baotou Medical College,Inner Mongolia Baotou 014040,China;I nstitute of Nutrition and Food Health,Baotou Medical College,Inner Mongolia Baotou 014040,China)

机构地区：[1]包头医学院公共卫生学院,内蒙古包头014040 [2]包头医学院营养与食品健康研究所,内蒙古包头014040

出　　处：《中国食品卫生杂志》2022年第6期1361-1365,共5页Chinese Journal of Food Hygiene

基　　金：国家自然科学基金(81560150);内蒙古自治区自然科学基金(2021LHMS08017);内蒙古自治区卫生健康委医疗卫生科技计划项目(202201368);内蒙古高校青年科技英才(NJYT22119)。

摘　　要：熊果酸是一种天然存在的三萜类化合物,具有广泛的生物活性,可调血脂、抗炎、抗癌、抗氧化、保护心脏、肝脏、抗骨骼肌萎缩、抗病毒等。熊果酸众多的生物功能使其成为新的预防及治疗多种疾病有前途的候选物。另外,我国有丰富的植物中医药资源,熊果酸可以从许多常见植物中获得,比如沙棘、薰衣草、苹果的果皮等。熊果酸及其合成衍生物也涉及一系列与疾病预防相关的领域。因此,探讨熊果酸的功能性作用对应用于临床具有十分重要的意义。本文总结熊果酸的功能性作用及相关机制从而为治疗及预防其他疾病提供新的思路。Ursolic acid is a naturally occurring triterpenoid compound with a wide range of biological activities,such as blood lipids regulation,anti-inflammatory,anti-cancer,anti-oxidation,heart and liver protection,anti-skeletal muscle atrophy,anti-virus,etc.Due to its numerous biological functions,it has become a promising candidate for the prevention and treatment of various diseases.In addition,China has abundant plant resources of traditional Chinese medicine.Ursolic acid can be obtained from many common plants,such as sea buckthorn,lavender and apple peel.Ursolic acid and its synthetic derivatives are also involved in a series of fields related to disease prevention.Therefore,it is very important to explore the functional role of ursolic acid for clinical use.This article summarizes the functional effects of ursolic acid and related mechanisms to provide new ideas for the treatment and prevention of other diseases.

关 键 词：熊果酸 生物活性 机制 疾病 

分 类 号：R155[医药卫生—营养与食品卫生学]