食管癌放疗不同敏感性患者PBK/TOPK mRNA表达观察  

Observation of PBK/TOPK mRNA Expression in Patients with Different Sensitivities to Radiotherapy for Esophageal Cancer

作　　者：黄尚校 黄剑锋[1] 莫敦昌 HUANG Shangxiao;HUANG Jianfeng;MO Dunchang(Department of Radiotherapy,Nanning Second People’s Hospital,Nanning City,Guangxi 530031)

机构地区：[1]广西南宁市第二人民医院放疗科,530031

出　　处：《医学理论与实践》2023年第5期742-745,共4页The Journal of Medical Theory and Practice

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(Z20210026)。

摘　　要：目的:探讨食管癌放疗不同敏感性患者PDZ结合激酶/T-LAK细胞来源的蛋白激酶(PBK/TOPK)表达差异。方法:回顾性分析我院2019年10月—2021年10月收治的94例食管癌患者的临床资料,所有患者入院后均行放疗治疗,依据患者短期疗效分为放疗敏感组(n=61)与放疗抵抗组(n=33)。比较两组患者性别、年龄、身体质量指数、肿瘤位置、病变长度、临床分期、病理类型、卡式(Karnofsky)功能状态评分、最大横径、血管内皮生长因子(VEGF)、PBK/TOPK差异。通过ROC分析最大横径、PBK/TOPK、VEGF预测食管癌放疗敏感性的价值,并采用多因素Logistic回归分析明确食管癌放疗敏感性的影响因素。结果:94例患者放疗结束后完全缓解4例,部分缓解57例,疾病稳定21例,疾病进展12例,放疗敏感共计61例,占64.89%。两组性别、年龄、身体质量指数、肿瘤位置、病变长度、临床分期、病理类型、Karnofsky功能状态评分比较差异无统计学意义(P>0.05);放疗抵抗组患者低分化占比显著高于放疗敏感组,肿瘤最大横径、PBK/TOPK、VEGF水平显著高于放疗敏感组,差异有统计学意义(P<0.05);经ROC分析,最大横径≥4.371cm、PBK/TOPK≥10.282、VEGF≥212.693ng/L是食管癌放疗敏感性的最佳截断值(P<0.05);Logistic回归分析显示最大横径≥4.371cm、PBK/TOPK≥10.282、VEGF≥212.693ng/L、低分化是食管癌放疗敏感性的影响因素(P<0.05)。结论:食管癌放疗敏感性与肿瘤最大横径、分化程度、PBK/TOPK、VEGF水平有关,放疗抵抗患者PBK/TOPK水平显著较高,需密切关注。Objective:To investigate the different expression of PDZ-bound kinase/T-LAK cell-derived protein kinase(PBK/TOPK)in patients with different sensitivities to radiotherapy for esophageal cancer.Methods:The clinical data of 94 patients with esophageal cancer admitted to our hospital from October 2019 to October 2021 were retrospectively analyzed,and all patients were treated with radiotherapy after admission,and were divided into radiotherapy sensitive group(n=61)and radiotherapy resistance group(n=33)according to the short-term efficacy of patients.Sex,age,body mass index,tumor location,lesion length,clinical stage,pathological type,Karnofsky functional status score,maximum transverse diameter,vascular endothelial growth factor(VEGF),and PBK/TOPK differences were compared between the two groups.The value of radiotherapy sensitivity for esophageal cancer was predicted by ROC analysis of maximum transverse diameter,PBK/TOPK,and VEGF,and the influencing factors of radiotherapy sensitivity of esophageal cancer were determined by multivariate Logistic regression analysis.Results:4 of 94 patients had complete remission after radiotherapy,57 patients had partial remission,21 patients had stable disease,12 patients had disease progression,and 61 patients were sensitive to radiotherapy,accounting for 64.89%.There was no statistically significant difference in the comparison of sex,age,body mass index,tumor location,lesion length,clinical stage,pathological type,and Karnofsky functional status score between the two groups(P>0.05);the proportion of low differentiation in patients in the radiotherapy resistance group was significantly higher than that in the radiation therapy-sensitive group,and the maximum transverse diameter,PBK/TOPK,and VEGF levels of tumors were significantly higher than those in the radiation-sensitive group(P<0.05);after ROC analysis,the maximum transverse diameter≥4.371cm,PBK/TOPK≥10.282,VEGF≥212.693ng/L were the best truncation values for radiotherapy sensitivity for esophageal cancer(P<0.05).Log

关 键 词：食管癌 放射治疗 PDZ结合激酶/T-LAK细胞来源的蛋白激酶 血管内皮生长因子 

分 类 号：R730.55[医药卫生—肿瘤] R735.1[医药卫生—临床医学]