幽门螺杆菌在抑郁症共病功能性消化不良患者中的感染特征研究  

Study on the infection characteristics of helicobacter pylori in patients with depression and comorbid functional dyspepsia

作　　者：周晓雪 黄建龙[2] 刘娇 韩啸 ZHOU Xiaoxue;HUANG Jianlong;LIU Jiao;HAN Xiao(Department of Gastroenterology,Zhejiang Xiaoshan Hospital,Affiliated to Hangzhou Normal University,Hangzhou 311200,Zhejiang,China;Department of Mental Health,Zhejiang Xiaoshan Hospital,Affiliated to Hangzhou Normal University,Hangzhou 311200,Zhejiang,China)

机构地区：[1]浙江萧山医院,杭州师范大学附属萧山医院消化内科,浙江杭州311200 [2]浙江萧山医院,杭州师范大学附属萧山医院心理卫生科,浙江杭州311200

出　　处：《中国现代医生》2023年第5期55-59,共5页China Modern Doctor

摘　　要：目的探讨幽门螺杆菌(helicobacter pylori,Hp)在抑郁症共病功能性消化不良(functional dyspepsia,FD)患者中的感染特征,为临床诊治提供依据。方法选取2019年7月至2021年7月浙江萧山医院心理卫生科及消化内科诊断为抑郁症共病FD的235例患者为研究对象,根据Hp感染情况分为Hp阳性组(n=83)和Hp阴性组(n=152),比较两组患者抑郁程度及消化不良症状发生情况,采用多因素Logistic回归分析抑郁症共病FD患者Hp感染的危险因素。结果Hp阳性组中,重度抑郁人数显著多于Hp阴性组患者,差异有统计学意义(P<0.05);Hp阳性组患者中上腹疼痛、餐后饱腹感与早饱感人数占比显著多于Hp阴性组患者,差异均有统计学意义(P<0.05);多因素Logistic回归分析结果显示,年龄、病程、与Hp感染者密切接触、睡眠质量是抑郁症共病FD患者Hp感染的独立危险因素。结论Hp感染与抑郁症共病FD有关,由年龄、病程、睡眠质量等影响因素及神经调节、内分泌、免疫反应与炎症反应等感染途径相互作用导致的。Objective To investigate the infection characteristics of helicobacter pylori(Hp)in patients with depression comorbid functional dyspepsia,and to provide evidence for clinical diagnosis and treatment.Methods A total of 235 patients diagnosed with comorbid FD of depression from July 2019 to July 2021 in the department of mental health and the department of gastroenterology of Zhejiang Xiaoshan Hospital were selected and divided into Hp-positive group(n=83)and Hp-negative group(n=152)according to Hp infection status.Multivariate Logistic regression was used to analyze the risk factors of Hp infection in patients with depression comorbid FD,and the degree of depression and the occurrence of dyspepsia symptoms were compared between the two groups.Results In the Hp-positive group,the number of patients with moderate and severe depression was significantly higher than that in the Hp-negative group,and the difference was statistically significant(P<0.05).The proportion of patients with postprandial fullness and early satiety epigastric pain,postprandial satiety and early satiety in the Hp-positive group were significantly higher than those in the Hp-negative group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that age,course of disease,close contact with Hp-infected patients,and sleep quality were independent risk factors for Hp.Conclusion Hp infection is associated with comorbid FD of depression,which is caused by the interaction of influencing factors such as age,course of disease,sleep quality,and infection pathways such as neuromodulation,endocrine,immune response and inflammatory response.

关 键 词：幽门螺杆菌 抑郁症共病功能性消化不良 感染特征 

分 类 号：R573[医药卫生—消化系统]