Progress in Mechanism of Astragalus membranaceus and Its Chemical Constituents on Multiple Sclerosis  

作　　者：PENG Yong DENG Xiang YANG Shan-shan NIE Wei TANG Yan-dan 

机构地区：[1]Department of Neurology,Affiliated First Hospital of Hunan Traditional Chinese Medical College,Zhuzhou,Hunan Province,412000,China

出　　处：《Chinese Journal of Integrative Medicine》2023年第1期89-95,共7页中国结合医学杂志（英文版）

基　　金：Supported by Creative Research Group of Affiliated First Hospital of Hunan Traditional Chinese Medical College,China(No.2021B-003);Key Plans of Hunan Administration of Traditional Chinese Medicine,China(No.201915);Natural Science Foundation of Hunan Province,China(No.2018JJ6043);Health and Family Planning Commission of Hunan Province,China(No.B20180815);Technology Plan Project of Zhuzhou City,Hunan Province,China(No.2021-009)。

摘　　要：The primary chemical components of Astragalus membranaceus include polysaccharides,saponins,flavonoids,and amino acids.Recent studies have shown that Astragalus membranaceus has multiple functions,including improving immune function and exerting antioxidative,anti-radiation,anti-tumor,antibacterial,antiviral,and hormone-like effects.Astragalus membranaceus and its extracts are widely used in clinical practice because they have obvious therapeutic effects against various autoimmune diseases and relatively less adverse reaction.Multiple sclerosis(MS)is an autoimmune disease of central nervous system(CNS),which mainly caused by immune disorder that leads to inflammatory demyelination,inflammatory cell infiltration,and axonal degeneration in the CNS.In this review,the authors analyzed the clinical manifestations of MS and experimental autoimmune encephalomyelitis(EAE)and focused on the efficacy of Astragalus membranaceus and its chemical components in the treatment of MS/EAE.

关 键 词：Astragalus membranaceus chemical components multiple sclerosis experimental autoimmune encephalomyelitis IMMUNOREGULATION 

分 类 号：R277.7[医药卫生—中医学]