Study on tongue coating microbes of bitter taste,sticky and greasy taste in chronic atrophic gastritis  

作　　者：CAO Yang GAI Xiao ZHENG Yixin Guo Benqiong NIU Jingbin QIAN Peng LING Jianghong LIU Guoping ZHENG Yu 

机构地区：[1]Shanghai Key Laboratory of Health Identification and Assessment,School of Basic Medical Sciences,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China [2]Department of Digestive Disease,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China [3]DepartmentⅡof Digestive Disease,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

出　　处：《Journal of Traditional Chinese Medicine》2023年第1期160-167,共8页中医杂志（英文版）

基　　金：Supported by Natural Science Foundation-funded Project:Diagnosis Model of Chronic Atrophic Gastritis with Damp-Heat Syndrome Based on Complex Biological Network Technology(No.81873236);Shanghai Key Laboratory:Health Identification and Assessment(No.21DZ2271000)。

摘　　要：OBJECTIVE:To objectively reveal the relationship between tongue coating microbes and bitter taste,sticky and greasy taste in chronic atrophic gastritis(CAG)patients.METHODS:16S rRNA high-throughput sequencing was used to detect bacterial diversity and community composition of tongue coating microbes from samples of CAG patients.LEfSe algorithm was used for discovering the different tongue coating microbes in CAG patients with or without bitter taste,also that in CAG patients with or without sticky and greasy taste.RESULTS:We respectively compared the features of tongue coating microbes in bitter taste,sticky and greasy taste of CAG patients.At the genus level,25 tongue coating microbes were significantly different in CAG patients with bitter taste or without bitter taste;17 tongue coating microbes were significantly different in CAG patients with sticky and greasy taste or without sticky and greasy taste.Campylobacter and Rothia were closely related to CAG patients with bitter taste.Enterococcus,Serratia,Leptotrichia and Selenomonas were closely related to CAG patients with stick and greasy taste.CONCLUSION:Campylobacter and Rothia possibly contribute to bitter taste of CAG patients,and Enterococcus,Serratia,Leptotrichia and Selenomonas contribute to stick and greasy taste of CAG patients,which is potential for the diagnosis and treatment of CAG.

关 键 词：gastritis atrophic TASTE CAMPYLOBACTER ENTEROCOCCUS SERRATIA Leptotrichia Selenomonas 

分 类 号：R573[医药卫生—消化系统]