大黄?虫胶囊联合心得安治疗乙肝肝硬化门脉高压症临床观察  

Clinical Observation on Dahuang Zhechong Capsules and Propranolol in the Treatment of Portal Hypertension of Hepatitis B Cirrhosis

作　　者：吴铁雄 刘旭东[2] 朱沪敏 黄露 李品桦 WU Tiexiong;LIU Xudong;ZHU Humin;HUANG Lu;LI Pinghua(Guangxi University of Chinese Medicine,Nanning 530001,China;Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530000,China)

机构地区：[1]广西中医药大学,广西南宁530001 [2]广西中医药大学附属瑞康医院,广西南宁530000

出　　处：《西部中医药》2023年第2期102-105,共4页Western Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81473532);2018年广西一流学科建设项目重点课题(2018XK084);广西中医药适宜技术开发与推广项目(GZSY21-29);广西中医药大学研究生教育创新计划(YCSY20190077)。

摘　　要：目的:观察大黄?虫胶囊联合心得安治疗门静脉高压症的临床疗效。方法:选择75例乙肝肝硬化门脉高压症患者,随机分为3组。A组给予心得安口服,B组给予心得安+大黄?虫胶囊口服,C组给予心得安+扶正化瘀胶囊口服,疗程6个月。观察3组治疗前后肝功能、脾脏大小、门静脉及脾静脉内径,肝脏硬度、脂肪衰减等指标变化情况。结果:治疗后,各组谷丙转氨酶、谷草转氨酶水平均较治疗前降低(P<0.05),但治疗后各组间比较,差异无统计学意义(P>0.05)。治疗后,与A组比较,B组及C组肝硬度值及脂肪衰减值均降低(P<0.05);治疗后B组与C组比较,肝硬度值及脂肪衰减值差异无统计学意义(P>0.05)。治疗后,与A组比较,B组门静脉内径、脾脏厚度与长度均降低(P<0.05);与C组比较,B组脾脏长度缩小(P<0.05)。各组间治疗前后脾静脉内径比较,差异无统计学意义(P>0.05)。结论:心得安联合大黄蛰虫胶囊治疗乙肝肝硬化门脉高压患者,具有较为显著的临床疗效,可缩小脾脏及门静脉内径,降低肝脏硬度。Objective: To investigate clinical effects of Dahuang Zhechong capsules joined with propranolol in the treatment of portal hypertension. Methods: All 75 patients were randomized into three groups, A group took propranolol orally, B group accepted propranolol and Dahuang Zhechong capsules, and C group oral administration of propranolol and Fuzheng Huayu capsules, the course of the treatment was six months. To observe liver function, the size of spleen, inner diameters of portal vein and splenic vein, hepatic hardness, fat attenuation and others in three groups before and after the treatment. Results: After the treatment, the levels of glutamic-pyruvic transaminase and glutamic oxalacetic transaminase in different groups were lower than these before the treatment(P<0.05), the difference had no statistical meaning between different groups after the treatment(P>0.05). After the treatment, compared with A group, hepatic hardness and fat attenuation of B and C groups decreased(P<0.05);when B group was compared with C group after the treatment, the difference showed no statistical meaning in hepatic hardness and fat attenuation(P>0.05). After the treatment, inner diameters of portal vein, splenic thickness and length in B group reduced compared with these of A group(P<0.05);compared with C group, splenic length shortened in B group(P<0.05). The difference showed no statistical meaning in inner diameters of splenic vein between different groups before and after the treatment(P>0.05). Conclusion: Propranolol and Dahuang Zhechong capsules have the noticeable clinical effects in treating the patients with portal hypertension of hepatitis B cirrhosis, it can shorten the diameter of splenic and portal veins, reduce the hepatic hardness.

关 键 词：肝硬化 门静脉高压 大黄?虫胶囊 心得安 

分 类 号：R575.2[医药卫生—消化系统]