Sonazoid超声造影全过程引导在肝脏占位性病变穿刺活检中的应用研究  

Application of Sonazoid contrast-enhanced ultrasound real-time guided biopsy in liver space-occupying lesions

作　　者：缪伎玄 邹大中[1] 赵可[2] 茅卫东[3] 张芳霞[1] MIAO Jixuan;ZOU Dazhong;ZHAO Ke;MAO Weidong;ZHANG Fangxia(Department of Ultrasound,Jiangyin People’s Hospital,Jiangyin 214400,Jiangsu Province,China;Department of Pathology,Jiangyin People’s Hospital,Jiangyin 214400,Jiangsu Province,China;Department of Oncology,Jiangyin People’s Hospital,Jiangyin 214400,Jiangsu Province,China)

机构地区：[1]江阴市人民医院超声科,江苏江阴214400 [2]江阴市人民医院病理科,江苏江阴214400 [3]江阴市人民医院肿瘤科,江苏江阴214400

出　　处：《肿瘤影像学》2023年第1期53-58,共6页Oncoradiology

基　　金：无锡市科技发展医疗卫生指导性计划(锡科社2020-259-50)。

摘　　要：目的:通过比较常规超声引导和全氟丁烷微球超声造影(Sonazoid-contrast-enhanced ultrasound,S-CEUS)引导的肝脏占位性病变组织病理学诊断结果,评估S-CEUS引导在肝脏占位性病变穿刺活检中的价值。方法:选取2021年1—6月江阴市人民医院治疗的肝脏占位性病变患者65例,病灶65个。其中35个病灶在超声引导下进行穿刺活检,其余30个病灶在S-CEUS引导下进行穿刺活检,通过两组患者的病理学检查结果比较取材成功率。采用独立样本t检验及χ^(2)检验,分析组间分类变量的差异。结果:S-CEUS引导下的取材成功率明显高于超声引导(93.3%vs 74.3%,P<0.05)。当对直径<3.0 cm的病灶进行穿刺活检时,S-CEUS引导下的取材成功率也显著高于超声引导(94.1%vs 61.1%,P<0.05)。与超声引导相比,S-CEUS引导的单次取材成功率更高(79.0%vs 56.0%,P<0.05)。结论:使用S-CEUS全过程引导,能够提高经皮肝占位性病变穿刺活检的成功率,特别在肝脏小病灶的活检中具有较高的应用价值。Objective:To evaluate the value of Sonazoid-contrast-enhanced ultrasound(S-CEUS)guided needle biopsy in liver space-occupying lesions,by comparing the pathological diagnosis results of liver space-occupying lesions guided by conventional ultrasonography(US)and S-CEUS.Methods:Sixty-flve patients with liver space-occupying lesions treated in Jiangyin People’s Hospital from January to June 2021 were selected,with 65 lesions.35 lesions were subjected to needle biopsy guided by US,and 30 lesions were subjected to needle biopsy guided by S-CEUS.The sampling success rate was compared by the pathological diagnosis results of the two groups of patients.Independent sample t test and χ^(2) test were used to analyze the differences in categorical variables between groups.Results:The sampling success rate guided by S-CEUS was signiflcantly higher than that guided by US(93.3%vs 74.3%,P<0.05).When needle biopsy was performed on smaller lesions(maximum diameter<3.0 cm),the sampling success rate under S-CEUS-guided biopsy was also signiflcantly higher than that under US guidance(94.1%vs 61.1%,P<0.05).Compared with US,S-CEUS-guided single sampling success rate was higher(79.0%vs 56.0%,P<0.05).Conclusions:S-CEUS real-time guidance can improve the success rate of liver space-occupying lesions biopsy,especially in small liver lesions biopsy has high application value.

关 键 词：全氟丁烷微球 超声造影 肝脏占位性病变 实时活检 

分 类 号：R735.7[医药卫生—肿瘤] R445.1[医药卫生—临床医学]